Nuclear transport of galectin-3 and its therapeutic implications.
Nuclear transport of galectin-3 and its therapeutic implications.
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DOI：
10.1016/j.semcancer.2014.03.004
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发表时间：
2014-08
影响因子：
14.5
通讯作者：
Nangia-Makker P
中科院分区：
文献类型：
--
作者：
Funasaka T;Raz A;Nangia-Makker P
Galectin-3是β-半乳糖苷结合基因家族的成员之一，是一种多功能蛋白质，可调节细胞生长、细胞粘附、细胞间相互作用、细胞凋亡、血管生成和mRNA加工等多种生物学功能。其独特的结构使其能够以碳水化合物依赖或不依赖的方式与大量配体相互作用。半乳糖凝集素-3主要是一种胞质蛋白，但可以很容易地穿过细胞内和质膜，易位到细胞核，线粒体或得到外部。根据细胞类型、体外特定实验条件、癌症类型和阶段，半乳糖凝集素-3据报道仅为细胞质，主要为细胞核或分布在两个区室之间。本文综述了galectin-3在细胞核和细胞质之间穿梭的动力学、galectin-3的核转运机制、galectin-3与β-catenin信号通路成员的特异性相互作用如何影响肿瘤进展及其作为治疗靶点的意义。
Galectin-3, a member of β-galactoside-binding gene family is a multi-functional protein, which regulates pleiotropic biological functions such as cell growth, cell adhesion, cell-cell interactions, apoptosis, angiogenesis and mRNA processing. Its unique structure enables it to interact with a plethora of ligands in a carbohydrate dependent or independent manner. Galectin-3 is mainly a cytosolic protein, but can easily traverse the intracellular and plasma membranes to translocate into the nucleus, mitochondria or get externalized. Depending on the cell type, specific experimental conditions in vitro, cancer type and stage, galectin-3 has been reported to be exclusively cytoplasmic, predominantly nuclear or distributed between the two compartments. In this review we have summarized the dynamics of galectin-3 shuttling between the nucleus and the cytoplasm, the nuclear transport mechanisms of galectin-3, how its specific interactions with the members of β-catenin signaling pathways affect tumor progression, and its implications as a therapeutic target.
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DOI：
10.1016/j.bbrc.2011.07.099
发表时间：
2011-08-26
影响因子：
3.1
作者：
Cheng, Yi-Lin;Huang, Wei-Ching;Lin, Chiou-Feng
通讯作者：
Lin, Chiou-Feng
影响因子：
7.5
作者：
Boscher, Cecile;Dennis, James W.;Nabi, Ivan R.
通讯作者：
Nabi, Ivan R.
影响因子：
6.4
作者：
Agudo, D;Gómez-Esquer, F;Schneider, J
通讯作者：
Schneider, J
影响因子：
11.8
作者：
D'Angelo, Maximilian A.;Gomez-Cavazos, J. Sebastian;Mei, Arianna;Lackner, Daniel H.;Hetzer, Martin W.
通讯作者：
Hetzer, Martin W.
影响因子：
4.3
作者：
Braeuer, Russell R.;Shoshan, Einav;Bar-Eli, Menashe
通讯作者：
Bar-Eli, Menashe