Behavioral economic analysis of the reinforcing effects of "bath salts" mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats.
Behavioral economic analysis of the reinforcing effects of "bath salts" mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats.
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DOI：
10.1007/s00213-018-5046-x
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发表时间：
2019-03
影响因子：
3.4
通讯作者：
Collins GT
中科院分区：
文献类型：
--
作者：
Gannon BM;Mesmin MP;Sulima A;Rice KC;Collins GT
“浴盐”制剂通常含有合成卡西酮（例如，3,4-亚甲二氧基甲卡西酮 [methylone]、3,4-亚甲二氧基吡咯戊酮 [MDPV]）和咖啡因的组合，并且有证据表明，合成卡西酮和咖啡因的混合物（例如，MDPV+咖啡因或methylone+咖啡因）可能比添加剂的预期更有效和/或更有效的强化剂互动。使用需求曲线分析来比较MDPV和甲基酮与MDPV+咖啡因和甲基酮+咖啡因的混合物的增强效果。雄性 Sprague-Dawley 大鼠在固定比例 (FR) 1 强化方案下获得美酮自我给药 (0.32 mg/kg/inf)，并在 FR5 强化方案下生成美酮 (0.01–1 mg/kg/inf) 的完整剂量反应曲线。然后根据以下系列，通过增加疗程中的 FR，获得美酮、MDPV、咖啡因、以及美酮+咖啡因和 MDPV+咖啡因混合物的需求曲线：3、10、18、32、56、100、178 等。87.5% 的大鼠迅速获得了美酮的自我给药，并在一定剂量范围内维持，产生倒 U 形剂量反应曲线。各个成分的需求排序为MDPV>甲基酮>咖啡因。对 3:1（但不是 10:1）甲基酮 + 咖啡因混合物的需求大于单独甲基酮的需求，并且对单独 MDPV 的需求与评估的两种 MDPV+咖啡因混合物相似。这些研究提供了额外的证据，表明尽管甲基酮是一种有效的强化剂，但与单独使用甲基酮相比，将甲基酮与咖啡因结合可增强强化效果。因此，滥用含有合成卡西酮和咖啡因的“浴盐”制剂可能比仅含有合成卡西酮的制剂具有更高的滥用倾向。
“Bath salts” preparations often contain combinations of synthetic cathinones (e.g., 3,4methylenedioxymethcathinone [methylone], 3,4-methylenedioxypyrovalerone [MDPV]) and caffeine, and evidence suggests that mixtures of synthetic cathinones and caffeine (e.g., MDPV+caffeine or methylone+caffeine) can be more potent and/or effective reinforcers than predicted for an additive interaction. To use demand curve analyses to compare the reinforcing effectiveness of MDPV and methylone to mixtures of MDPV+caffeine and methylone+caffeine. Male Sprague-Dawley rats acquired methylone self-administration (0.32 mg/kg/inf) under a fixed ratio (FR) 1 schedule of reinforcement, and generated full dose-response curves for methylone (0.01–1 mg/kg/inf) under an FR5 schedule of reinforcement. Demand curves were then obtained for methylone, MDPV, caffeine, and methylone+caffeine and MDPV+caffeine mixtures by increasing the FR across sessions according to the following series: 3, 10, 18, 32, 56, 100, 178, etc. Self-administration of methylone was rapidly acquired by 87.5% of rats and was maintained across a range of doses, producing an inverted U-shaped dose-response curve. Rank order demand for the individual constituents was MDPV>methylone>caffeine. Demand for the 3:1 (but not 10:1) methylone+caffeine mixture was greater than that for methylone alone, and demand for MDPV alone was similar to both MDPV+caffeine mixtures evaluated. These studies provide additional evidence that although methylone is an effective reinforcer, combining methylone with caffeine results in an enhanced reinforcing effectiveness compared to methylone alone. Thus, abused “bath salts” preparations containing synthetic cathinones and caffeine may have higher abuse liability than preparations containing only synthetic cathinones.
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影响因子：
7.6
作者：
Gannon, Brenda M.;Galindo, Kayla I.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
3.4
作者：
GRIFFITHS, RR;BRADFORD, LD;BRADY, JV
通讯作者：
BRADY, JV
影响因子：
7.6
作者：
Gannon, Brenda M.;Baumann, Michael H.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.
影响因子：
3.6
作者：
DERLET, RW;TSENG, JC;ALBERTSON, TE
通讯作者：
ALBERTSON, TE
DOI：
10.1124/jpet.116.239376
发表时间：
2017-04-01
影响因子：
3.5
作者：
Gannon, Brenda M.;Galindo, Kayla I.;Collins, Gregory T.
通讯作者：
Collins, Gregory T.