Th17 cells and their associated cytokines in liver diseases.
Th17 cells and their associated cytokines in liver diseases.
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DOI：
10.1038/cmi.2010.5
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发表时间：
2010-07
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
辅助性T细胞17（Th 17）是新近发现的辅助性T细胞亚群，在宿主防御细胞外细菌以及自身免疫性疾病的发病机制中发挥重要作用。Th 17细胞的功能是通过产生几种细胞因子介导的，包括白细胞介素（IL）-17和IL-22。最近的研究表明，IL-17+细胞的频率在各种慢性肝病中显著升高，包括酒精性肝病、病毒性肝炎和肝细胞癌。IL-17受体实际上在所有类型的肝细胞上表达，而IL-22受体表达限于肝中的上皮细胞，包括肝细胞。IL-17可能通过刺激多种类型的肝非实质细胞产生促炎细胞因子和趋化因子而在诱导肝脏炎症中发挥重要作用，而IL-22似乎是促进肝细胞存活和增殖的重要因素。
T helper 17 (Th17) cells are a newly identified subset of T helper cells that play important roles in host defense against extracellular bacteria as well as in the pathogenesis of autoimmune disease. The functions of Th17 cells are mediated via the production of several cytokines including interleukin (IL)-17 and IL-22. Recent studies show that the frequency of IL-17+ cells is significantly elevated in a variety of chronic liver diseases including alcoholic liver disease, viral hepatitis and hepatocellular carcinoma. IL-17 receptor is expressed virtually on all types of liver cells, while IL-22 receptor expression is restricted to epithelial cells including hepatocytes in the liver. IL-17 seems to play an important role in inducing liver inflammation via stimulating multiple types of liver nonparenchymal cells to produce proinflammatory cytokines and chemokines, while IL-22 appears to be an important factor in promoting hepatocyte survival and proliferation.
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影响因子：
13.6
作者：
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通讯作者：
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
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