Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells.
Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells.
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肺癌中树突状细胞特异性细胞间粘附分子捕获非整合素相关蛋白的低表达与脑转移和自然杀伤细胞显着相关
DOI：
10.1007/s11010-015-2465-4
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发表时间：
2015-09
影响因子：
4.3
通讯作者：
Zuo Y
中科院分区：
文献类型：
--
作者：
Liu X;Zhang H;Su L;Yang P;Xin Z;Zou J;Ren S;Zuo Y
树突状细胞特异性细胞间黏附分子抓取非整合素相关蛋白(DC-SIGNR)是一种II型跨膜蛋白，已被报道与多种病原体结合并参与免疫调节。但DC-SIGNR水平与肺癌的关系尚不清楚。为探讨DC-SIGNR在肺癌诊断中的临床意义，采用酶联免疫吸附试验(EL ISA)检测了173例肺癌患者和134例健康人血清DC-SIGNR水平。结果表明，肺癌患者血清DC-SIGNR水平明显低于健康对照组(P=0.0003)。DC-SIGNR的临界值3.8998 ng/L预测肺癌的敏感性为78.03%，特异性为49.25%(曲线下面积=0.6212，P=0.0003)。有脑转移的肺癌患者血清DC-SIGNR水平显著高于无脑转移的患者(P=0.0283)。此外，肺癌患者血清DC-SIGNR浓度与血清自然杀伤细胞百分率也呈显著正相关(P=0.0017)。另外，免疫组织化学检测显示，DC-SIGNR在31例肺癌和13例肺结核患者肺组织中的表达明显低于18例正常肺组织(P=0.0418，0.0289)，而在肺结核组织和肺癌组织中的表达差异无统计学意义(P=0.2696)。这些结果提示DC-SIGNR可能是一种有潜力用于肺癌临床研究的生物分子，但其潜在的作用有待于进一步的研究。
Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein which has been reported to bind a variety of pathogens as well as participate in immunoregulation. But the association between the level of DC-SIGNR and lung cancer is unknown. To investigate the clinical diagnostic significance of DC-SIGNR in lung cancer, we investigated serum DC-SIGNR levels in 173 lung cancer patients and 134 healthy individuals using enzyme-linked immunosorbent assay (ELISA). Results showed that serum DC-SIGNR levels in lung cancer patients were lower than that in healthy controls (P= 0.0003). A cut-off value of 3.8998 ng/L for DC-SIGNR predicted the presence of lung cancer with 78.03 % sensitivity and 49.25 % specificity (area under the curve = 0.6212,P= 0.0003). Strikingly, serum DC-SIGNR levels were significantly higher in lung cancer patients with brain metastasis compared to those without metastasis (P= 0.0283). Moreover, the serum concentrations of DC-SIGNR in lung cancer patients also correlated significantly with serum natural killer cells percentage (P= 0.0017). In addition, immunohistochemistry assay demonstrated that the expression of DC-SIGNR in lung tissues of 31 lung cancer patients and 13 tuberculosis patients was significantly lower than that in 18 normal lung tissues (P= 0.0418, 0.0289), and there is no significant difference between tuberculosis tissues and lung cancer tissues (P= 0.2696). These results suggest that DC-SIGNR maybe a promising biological molecule that has the potential for clinical research of lung cancer, whereas its underlying roles are needed to be investigated in further studies.
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影响因子：
3.7
作者：
Jiang Y;Zhang C;Chen K;Chen Z;Sun Z;Zhang Z;Ding D;Ren S;Zuo Y
通讯作者：
Zuo Y
影响因子：
30.8
作者：
Chan VS;Chan KY;Chen Y;Poon LL;Cheung AN;Zheng B;Chan KH;Mak W;Ngan HY;Xu X;Screaton G;Tam PK;Austyn JM;Chan LC;Yip SP;Peiris M;Khoo US;Lin CL
通讯作者：
Lin CL
影响因子：
11.8
作者：
Kirk, Gregory D.;Merlo, Christian;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
56.9
作者：
Feinberg, H;Mitchell, DA;Weis, WI
通讯作者：
Weis, WI
影响因子：
6.4
作者：
Baccarelli, Andrea;Hou, Lifang;Chow, Wong-Ho
通讯作者：
Chow, Wong-Ho