Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation.
Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation.
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三碘甲状腺原氨酸（T3）通过甲状腺激素受体α介导的脂肪细胞祖细胞增殖促进棕色脂肪增生
DOI：
10.1038/s41467-022-31154-1
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发表时间：
2022-06-13
影响因子：
16.6
通讯作者：
Ying, Hao
中科院分区：
文献类型：
--
作者：
Liu, Shengnan;Shen, Siyi;Yan, Ying;Sun, Chao;Lu, Zhiqiang;Feng, Hua;Ma, Yiruo;Tang, Zhili;Yu, Jing;Wu, Yuting;Gereben, Balazs;Mohacsik, Petra;Fekete, Csaba;Feng, Xiaoyun;Yuan, Feixiang;Guo, Feifan;Hu, Cheng;Shao, Mengle;Gao, Xin;Zhao, Lin;Li, Yuying;Jiang, Jingjing;Ying, Hao
甲状腺激素（TH）控制的棕色脂肪组织（BAT）的募集过程尚未完全了解。在这里，我们表明，长期治疗T3，TH的活性形式，通过促进TH受体α介导的脂肪祖细胞增殖，通过增生增加雄性小鼠肩胛间BAT的产热能力的募集。我们的单细胞分析揭示了肩胛间BAT的脂肪祖细胞内的异质性和分层轨迹。进一步的分析表明，T3通过Myc对糖酵解的作用机制，促进细胞状态从更干细胞样状态向更定向的成脂状态转变，并促进脂肪细胞祖细胞中细胞周期向有丝分裂状态的进展。我们的研究结果阐明了在BAT中的脂肪祖细胞中TH作用的机制，并为更好地理解TH对BAT库中增生性生长和适应性产热的影响提供了一个框架。甲状腺激素（TH）的作用通过不完全理解的机制调节棕色脂肪组织产热能力。在这里，作者报告说，T3，TH的活性形式，通过甲状腺激素受体α介导的棕色脂肪组织脂肪细胞祖细胞的增生增加产热能力。
The thyroid hormone (TH)-controlled recruitment process of brown adipose tissue (BAT) is not fully understood. Here, we show that long-term treatment of T3, the active form of TH, increases the recruitment of thermogenic capacity in interscapular BAT of male mice through hyperplasia by promoting the TH receptor α-mediated adipocyte progenitor cell proliferation. Our single-cell analysis reveals the heterogeneous nature and hierarchical trajectory within adipocyte progenitor cells of interscapular BAT. Further analyses suggest that T3 facilitates cell state transition from a more stem-like state towards a more committed adipogenic state and promotes cell cycle progression towards a mitotic state in adipocyte progenitor cells, through mechanisms involving the action of Myc on glycolysis. Our findings elucidate the mechanisms underlying the TH action in adipocyte progenitors residing in BAT and provide a framework for better understanding of the TH effects on hyperplastic growth and adaptive thermogenesis in BAT depot at a single-cell level. Thyroid hormone (TH) action regulates brown adipose tissue thermogenic capacity through incompletely understood mechanisms. Here the authors report that T3, the active form of TH, increases thermogenic capacity via thyroid hormone receptor α-mediated hyperplasia of brown adipose tissue adipocyte progenitor cells.
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克隆衍生的成年人类棕色脂肪细胞的遗传和功能表征。
影响因子：
82.9
作者：
Shinoda, Kosaku;Luijten, Ineke H. N.;Hasegawa, Yutaka;Hong, Haemin;Sonne, Si B.;Kim, Miae;Xue, Ruidan;Chondronikola, Maria;Cypess, Aaron M.;Tseng, Yu-Hua;Nedergaard, Jan;Sidossis, Labros S.;Kajimura, Shingo
通讯作者：
Kajimura, Shingo
影响因子：
29
作者：
Martínez-Sánchez N;Seoane-Collazo P;Contreras C;Varela L;Villarroya J;Rial-Pensado E;Buqué X;Aurrekoetxea I;Delgado TC;Vázquez-Martínez R;González-García I;Roa J;Whittle AJ;Gomez-Santos B;Velagapudi V;Tung YCL;Morgan DA;Voshol PJ;Martínez de Morentin PB;López-González T;Liñares-Pose L;Gonzalez F;Chatterjee K;Sobrino T;Medina-Gómez G;Davis RJ;Casals N;Orešič M;Coll AP;Vidal-Puig A;Mittag J;Tena-Sempere M;Malagón MM;Diéguez C;Martínez-Chantar ML;Aspichueta P;Rahmouni K;Nogueiras R;Sabio G;Villarroya F;López M
通讯作者：
López M
DOI：
10.1016/j.bbadis.2013.05.027
发表时间：
2014-03
影响因子：
6.2
作者：
Sanchez-Gurmaches, Joan;Guertin, David A.
通讯作者：
Guertin, David A.
影响因子：
3.9
作者：
Kalinovich, Anastasia V.;de Jong, Jasper M. A.;Nedergaard, Jan
通讯作者：
Nedergaard, Jan
影响因子：
5.5
作者：
Shafer, Maxwell E. R.
通讯作者：
Shafer, Maxwell E. R.