Adipocyte lineages: tracing back the origins of fat.
Adipocyte lineages: tracing back the origins of fat.
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DOI：
10.1016/j.bbadis.2013.05.027
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发表时间：
2014-03
影响因子：
6.2
通讯作者：
Guertin, David A.
中科院分区：
文献类型：
--
作者：
Sanchez-Gurmaches, Joan;Guertin, David A.
关键词：
肥胖症的流行加强了了解控制脂肪组织发育的机制的努力。脂肪组织通常被分为白色脂肪组织(WAT)和棕色脂肪组织(BAT)，白色脂肪组织是人体主要的储能组织，棕色脂肪组织是人体非颤抖产热的中介组织。据推测，黄褐色脂肪细胞(白色棕色)可能代表第三类脂肪细胞。最近意识到棕色脂肪存在于成年人中，这表明增加棕色脂肪的能量消耗可能是对抗肥胖的一种治疗策略。为了了解脂肪组织的发育，几个研究小组正在追溯成熟脂肪细胞的起源，追溯到它们的成年前体和胚胎祖先。从这些研究中出现了一种模型，即棕色脂肪细胞起源于与骨骼肌共享的表达Myf5-Cre的前体，而所有白色脂肪细胞起源于Myf5阴性的前体。虽然这为为什么BAT在代谢上比WAT更有利提供了一个合理的解释，但最近的研究表明，情况更复杂，因为白色脂肪细胞的亚群也来自Myf5-Cre表达的前体。谱系追踪研究进一步表明，血管系统可能提供了支持棕色和白色脂肪细胞前体细胞的利基；然而，脂肪细胞前体细胞的身份仍存在争议。脂肪细胞来源的差异可以解释不同储存库之间的代谢异质性和/或影响身体脂肪模式，特别是在脂肪营养不良疾病中。在这里，我们讨论了对脂肪组织起源的最新见解，重点是小鼠的谱系追踪研究，谱系之间的新陈代谢或信号变化如何影响体内脂肪分布，以及仍未解决的问题。
The obesity epidemic has intensified efforts to understand the mechanisms controlling adipose tissue development. Adipose tissue is generally classified as white adipose tissue (WAT), the major energy storing tissue, or brown adipose tissue (BAT), which mediates non-shivering thermogenesis. It is hypothesized that brite adipocytes (brown in white) may represent a third adipocyte class. The recent realization that brown fat exist in adult humans suggests increasing brown fat energy expenditure could be a therapeutic strategy to combat obesity. To understand adipose tissue development, several groups are tracing the origins of mature adipocytes back to their adult precursor and embryonic ancestors. From these studies emerged a model that brown adipocytes originate from a precursor shared with skeletal muscle that expresses Myf5-Cre, while all white adipocytes originate from a Myf5-negative precursors. While this provided a rational explanation to why BAT is more metabolically favorable than WAT, recent work indicates the situation is more complex because subsets of white adipocytes also arise from Myf5-Cre expressing precursors. Lineage tracing studies further suggest that the vasculature may provide a niche supporting both brown and white adipocyte progenitors; however, the identity of the adipocyte progenitor cell is under debate. Differences in origin between adipocytes could explain metabolic heterogeneity between depots and/or influence body fat patterning particularly in lipodystrophy disorders. Here, we discuss recent insights into adipose tissue origins highlighting lineage-tracing studies in mice, how variations in metabolism or signaling between lineages could affect body fat distribution, and the questions that remain unresolved.
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影响因子：
3.7
作者：
Baglioni S;Cantini G;Poli G;Francalanci M;Squecco R;Di Franco A;Borgogni E;Frontera S;Nesi G;Liotta F;Lucchese M;Perigli G;Francini F;Forti G;Serio M;Luconi M
通讯作者：
Luconi M
DOI：
10.1242/dev.002642
发表时间：
2007-06
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Billon N;Iannarelli P;Monteiro MC;Glavieux-Pardanaud C;Richardson WD;Kessaris N;Dani C;Dupin E
通讯作者：
Dupin E
影响因子：
4.3
作者：
Cinti S
通讯作者：
Cinti S
影响因子：
11.2
作者：
Carracedo A;Alimonti A;Pandolfi PP
通讯作者：
Pandolfi PP
影响因子：
4.1
作者：
Casteilla, Louis;Planat-Benard, Valerie;Cousin, Beatrice
通讯作者：
Cousin, Beatrice