Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration.
Identification of environmental sounds and melodies in syndromes of anterior temporal lobe degeneration.
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DOI：
10.1016/j.jns.2015.03.007
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发表时间：
2015-05-15
影响因子：
4.4
通讯作者：
Warren, Jason D.
中科院分区：
文献类型：
--
作者：
Golden, Hannah L.;Downey, Laura E.;Fletcher, Philip D.;Mahoney, Colin J.;Schott, Jonathan M.;Mummery, Catherine J.;Crutch, Sebastian J.;Warren, Jason D.
关键词：
语义性痴呆及其他颞叶前部退化综合征对非言语声音的识别可能决定临床症状，并有助于确定表型特征。然而，在这些综合征中，非言语听觉语义功能尚未得到广泛研究。在此，我们研究了语义性痴呆患者（SD组；n = 9）以及表现出行为衰退的颞叶前部萎缩患者（TL组；n = 7，包括4例MAPT突变病例）在两个关键的非言语听觉领域——环境声音和旋律——中的语义处理，并与健康老年对照组（n = 20）进行了比较。我们使用新的、统一的模态内神经心理学程序评估了每个领域的听觉语义表现，该程序基于声音对的语义分类来确定声音识别。SD组和TL组在环境声音和旋律识别方面都表现出相似的总体损伤；个体患者通常对环境声音的识别优于对旋律的识别，然而在两组中也都出现了旋律识别相对于环境声音识别相对保留的情况。我们的研究结果表明，非言语听觉语义损伤是伴有颞叶前部萎缩的神经退行性综合征的一个常见特征。然而，听觉领域受累的情况在个体之间差异很大。
非言语听觉处理是语义记忆中一个研究不足的领域。
我们对颞叶萎缩患者的新型听觉语义任务进行了评估。
在整个队列中，环境声音和音乐处理受到的损伤程度相当。
个体患者可能表现出旋律处理相对保留。
非言语听觉缺陷与颞叶退化密切相关。
Recognition of nonverbal sounds in semantic dementia and other syndromes of anterior temporal lobe degeneration may determine clinical symptoms and help to define phenotypic profiles. However, nonverbal auditory semantic function has not been widely studied in these syndromes. Here we investigated semantic processing in two key nonverbal auditory domains – environmental sounds and melodies – in patients with semantic dementia (SD group; n = 9) and in patients with anterior temporal lobe atrophy presenting with behavioural decline (TL group; n = 7, including four cases with MAPT mutations) in relation to healthy older controls (n = 20). We assessed auditory semantic performance in each domain using novel, uniform within-modality neuropsychological procedures that determined sound identification based on semantic classification of sound pairs. Both the SD and TL groups showed comparable overall impairments of environmental sound and melody identification; individual patients generally showed superior identification of environmental sounds than melodies, however relative sparing of melody over environmental sound identification also occurred in both groups. Our findings suggest that nonverbal auditory semantic impairment is a common feature of neurodegenerative syndromes with anterior temporal lobe atrophy. However, the profile of auditory domain involvement varies substantially between individuals. Nonverbal auditory processing is an understudied area of semantic memory. We assessed novel auditory semantic tasks in patients with temporal lobe atrophy. Environmental sound and music processing were comparably impaired across the cohort. Individual patients may show relative sparing of melody processing. Nonverbal auditory deficits integrally accompany temporal lobe degeneration.
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影响因子：
0.8
作者：
Garrard, P;Carroll, E
通讯作者：
Carroll, E
影响因子：
5.7
作者：
Groussard, M.;Viader, F.;Platel, H.
通讯作者：
Platel, H.
DOI：
10.1111/j.1749-6632.2009.04557.x
发表时间：
2009-01-01
期刊：
NEUROSCIENCES AND MUSIC III: DISORDERS AND PLASTICITY
影响因子：
--
作者：
Peretz, Isabelle;Gosselin, Nathalie;Tillmann, Barbara
通讯作者：
Tillmann, Barbara
影响因子：
4.2
作者：
Clark, Camilla N.;Downey, Laura E.;Warren, Jason D.
通讯作者：
Warren, Jason D.
影响因子：
11
作者：
Omar, Rohani;Mahoney, Colin J.;Warren, Jason D.
通讯作者：
Warren, Jason D.