Characterization of the common acute lymphoblastic leukaemia antigen (CD10) as an activation molecule on mature human B cells
Characterization of the common acute lymphoblastic leukaemia antigen (CD10) as an activation molecule on mature human B cells
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常见急性淋巴细胞白血病抗原 (CD10) 作为成熟人类 B 细胞激活分子的表征
DOI：
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发表时间：
1990
影响因子：
4.6
通讯作者：
J. Hata
中科院分区：
文献类型：
--
作者：
N. Kiyokawa;Y. Kokai;K. Ishimoto;H. Fujita;J. Fujimoto;J. Hata
使用体内和体外系统分析了B细胞活化期间CD 10分子的不同表达模式。通过双色流式细胞术分析，发现CD 10在体内活化B细胞的特定阶段表达。在B细胞活化过程中，CD 10的表达似乎与其他活化相关B细胞抗原（包括L29、MA 6、OKT 9和OKT 10）的表达不同。尽管CD 10的表达与活化相关的B细胞抗原的表达相关，但当通过细胞重力进行分级时，CD 10+ B细胞可以分离为与表达其他活化相关的B细胞抗原的细胞不同的部分。特别地，检测到某些CD 10 + B细胞对静息B细胞抗原L30呈阳性。体外研究表明，CD 10 + B细胞在B细胞活化的早期阶段由CD 10-B细胞产生，并且在被金黄色葡萄球菌科万I活化后消失。总之，CD 10是在B细胞活化过程的早期阶段瞬时表达的抗原。15例Burkitt淋巴瘤组织中CD 10及其它抗原的表达。所有病例均为CD 10+，87%（13例）同时为L 30+。此外，6例CD 10 + L30+病例为L29+。这一观察结果表明，伯基特淋巴瘤的表型相似的B细胞在活化的早期阶段，那些同时表达CD 10和L30。本研究已经解剖了一个精确的表达模式的CD 10成熟B细胞活化在体外和体内，并可能牵连的组织发生的一个不好的特点B细胞淋巴瘤，即伯基特淋巴瘤。
Distinct expression pattern of CD10 molecules during B cell activation was analysed using in vivo and in vitro systems. By two‐colour flowcytometrical analysis, CD10 was found to be expressed at a specificstage of in vivo activating B cells. The expression of CD10 during B cell activation appeared to be unique from that of other activation‐related B cell antigens including L29, MA6, OKT9 and OKT10. Although the expression of CD10 was associated with that of the activation‐related B cell antigens, CD 10+ B cells could be separated in the distinct fractions to those expressing other activation‐related B cell antigens when fractionated by cell gravity. In particular, certain CD10+ B cells were detected positive for the resting B cell antigen, L30. In vitro studies revealed that CD10+ B cells arose from CD10‐ B cells at an early step of B cell activation, and disappeared lately when activated by Staphylococcus aureus Cowan I. Collectively, CD10 was an antigen transiently expressed at an early phase of B cell activation process. Expression of CD10 and other antigens on Burkitt's lymphomas (15 cases) was studied next. All cases were CD10+, and 87% (13 cases) were also L30+. In addition, six of CD10+ L30+ cases were L29+. This observation suggested that Burkitt's lymphomas were phenotypically similar to the B cells at an early phase of activation, those expressing CD10 and L30, simultaneously. The present study has dissected a precise expression pattern of CD10 on mature B cell activation in vitro and in vivo, and could be implicated for the histogenesis of one of the poorly characterized B cell lymphoma, namely Burkitt's lymphoma.
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影响因子：
20.3
作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
通讯作者：
M. Loken;V. O. Shah;Karen L. Dattilio;C. Civin
通过造血分化抗原鉴定的正常骨髓中常见的急性淋巴细胞白血病抗原阳性淋巴细胞亚群。
影响因子：
20.3
作者：
Ryan,D;Kossover,S;Mitchell,S;Frantz,C;Hennessy,L;Cohen,H
通讯作者：
Cohen,H
人类 B 淋巴细胞亚群。
DOI：
10.1016/0090-1229(81)90193-8
发表时间：
1981
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Dagg,MK;Levitt,D
通讯作者：
Levitt,D
从正常人骨髓中纯化常见急性淋巴细胞白血病抗原阳性细胞。
影响因子：
20.3
作者：
Hokland,P;Nadler,LM;Griffin,JD;Schlossman,SF;Ritz,J
通讯作者：
Ritz,J
B5，一种新的 B 细胞限制性激活抗原。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Freedman,AS;Boyd,AW;Anderson,KC;Fisher,DC;Schlossman,SF;Nadler,LM
通讯作者：
Nadler,LM