Estradiol and song affect female zebra finch behavior independent of dopamine in the striatum.

Estradiol and song affect female zebra finch behavior independent of dopamine in the striatum.
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雌二醇和鸣声影响雌性斑胸草雀的行为,与纹状体中的多巴胺无关。

DOI:
10.1016/j.physbeh.2009.07.003
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发表时间:
2009
影响因子:
2.9
通讯作者:
Wade,Juli
Wade,Juli
中科院分区:
医学3区
文献类型:
--
作者:
Svec,LaceA;Lookingland,KeithJ;Wade,Juli

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雌性鸣禽表现出对某些歌曲特征的偏好,但调节这些偏好的神经和激素机制尚不完全清楚。本研究旨在进一步探讨雌二醇的作用,以及评估多巴胺能系统的潜在作用,对歌曲的行为反应。成年雌性斑胸草雀用雌二醇处理,并暴露于辅导或未辅导的歌曲或沉默。行为进行了量化和神经化学的脑桥和纹状体的高效液相色谱法进行了检查。作为对照,还评价了这两个系统对雷氯必利(一种特异性D2受体拮抗剂)治疗的反应。这种操作不影响多巴胺(DA),但增加DOPAC和DOPAC/DA的比例。肾上腺素减少了两种行为的显示,远距离呼叫和视觉扫描,但对多巴胺能反应没有影响。听觉刺激暴露影响其他发声,但歌曲介绍并没有调节多巴胺或其代谢产物,多巴胺的水平,纹状体或纹状体。总的来说,这些结果表明,雌二醇和听觉刺激可以修改成年斑胸草雀的行为反应,但它们可能不会改变纹状体多巴胺神经元的DA浓度或营业额。
Female songbirds display preferences for certain song characteristics, but the neural and hormonal mechanisms mediating these preferences are not fully clear. The present study sought to further explore the role of estradiol, as well as assess potential roles of dopaminergic systems, on behavioral responses to song. Adult female zebra finches were treated with estradiol and exposed to tutored or untutored song or silence. Behavior was quantified and neurochemistry of the nucleus accumbens and striatum was examined with high performance liquid chromatography. As a control, the responses of these two systems to treatment with raclopride, a specific D2 receptor antagonist, were also evaluated. This manipulation did not affect dopamine (DA), but did increase DOPAC and the DOPAC/DA ratio. Estradiol reduced the display of two behaviors, distance calls and visual scanning, but had no effect on dopaminergic responses. Auditory stimulus exposure affected other vocalizations, but song presentation did not modulate the levels of DA or its metabolite, DOPAC in the nucleus accumbens or striatum. Collectively, the results suggest that both estradiol and auditory stimuli can modify the behavioral responses of adult zebra finches, but they may not change DA concentration or turnover in striatal dopamine neurons.
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