Microbial Dark Matter Investigations: How Microbial Studies Transform Biological Knowledge and Empirically Sketch a Logic of Scientific Discovery.
Microbial Dark Matter Investigations: How Microbial Studies Transform Biological Knowledge and Empirically Sketch a Logic of Scientific Discovery.
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DOI：
10.1093/gbe/evy031
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发表时间：
2018-03-01
影响因子：
3.3
通讯作者：
Bapteste E
中科院分区：
文献类型：
--
作者：
Bernard G;Pathmanathan JS;Lannes R;Lopez P;Bapteste E
微生物是地球上最古老、分布最广、遗传和代谢多样的生命形式。然而，它们在334年前才被发现，而且它们的多样性甚至在更晚的时候才开始被认真研究。出于这些原因，揭示新型微生物谱系和影响或涉及微生物的过程的微生物研究深刻（且重复）改变了生物学知识。考虑到环境基因组学数据集中分类学和功能未分配序列的定量流行，以及地球上未培养的微生物，我们建议将解开微生物暗物质确定为生物学家的中心优先事项。基于以前的微生物研究的经验发现，我们勾勒出一个发现的逻辑，有可能进一步突出微生物的未知。
Microbes are the oldest and most widespread, phylogenetically and metabolically diverse life forms on Earth. However, they have been discovered only 334 years ago, and their diversity started to become seriously investigated even later. For these reasons, microbial studies that unveil novel microbial lineages and processes affecting or involving microbes deeply (and repeatedly) transform knowledge in biology. Considering the quantitative prevalence of taxonomically and functionally unassigned sequences in environmental genomics data sets, and that of uncultured microbes on the planet, we propose that unraveling the microbial dark matter should be identified as a central priority for biologists. Based on former empirical findings of microbial studies, we sketch a logic of discovery with the potential to further highlight the microbial unknowns.
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影响因子：
3.3
作者：
Fondi M;Karkman A;Tamminen MV;Bosi E;Virta M;Fani R;Alm E;McInerney JO
通讯作者：
McInerney JO
影响因子：
15.5
作者：
Danczak RE;Johnston MD;Kenah C;Slattery M;Wrighton KC;Wilkins MJ
通讯作者：
Wilkins MJ
影响因子：
9.8
作者：
Bordenstein SR;Theis KR
通讯作者：
Theis KR
影响因子：
64.8
作者：
Burstein D;Harrington LB;Strutt SC;Probst AJ;Anantharaman K;Thomas BC;Doudna JA;Banfield JF
通讯作者：
Banfield JF
影响因子：
4.5
作者：
Da Cunha V;Gaia M;Gadelle D;Nasir A;Forterre P
通讯作者：
Forterre P