Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits.
Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits.
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DOI：
10.1038/s41598-017-10871-4
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发表时间：
2017-09-14
影响因子：
4.6
通讯作者：
Stergiakouli E
中科院分区：
文献类型：
--
作者：
Howe LJ;Erzurumluoglu AM;Davey Smith G;Rodriguez S;Stergiakouli E
许多精神病学特征在患病率、发病年龄、进展和预后方面具有性别二型性；性染色体可能在这些差异中发挥作用。在这项研究中，我们评估了Y染色体和线粒体DNA单倍群与性二态行为和精神特征的相关性。研究样本包括4,211名男性和4,009名女性线粒体DNA单倍组和4,788名男性Y染色体单倍组，他们是总部设在英国的雅芳亲子纵向研究(ALSPAC)的一部分。这些人群的不同子集被用行为和精神特征的测量进行评估，并使用Logistic回归来测量单倍组和这些特征之间的关联。我们队列中的大多数行为特征在男性和女性之间存在差异；然而，Y染色体和线粒体DNA单倍群与任何变量都没有关联。这些发现表明，如果Y染色体和线粒体DNA上存在与行为和精神特征变异相关的共同变异，那么它的影响很小。
Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.
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DOI：
10.1016/j.jaac.2014.10.003
发表时间：
2015-01
影响因子：
13.3
作者：
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影响因子：
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作者：
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