The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex.
The influence of mild hypothermia on reversal of rocuronium-induced deep neuromuscular block with sugammadex.
复制标题
温和体温过低对rocuronium诱导的深神经肌肉块逆转的影响。
DOI：
10.1186/1471-2253-15-7
复制
发表时间：
2015-01-21
影响因子：
2.2
通讯作者：
Lee BC
中科院分区：
文献类型：
--
作者：
Lee HJ;Kim KS;Jeong JS;Kim KN;Lee BC
由于手术室的低温环境，经常会引起轻度体温过低。该研究分析了患者在轻度低温下接受长时间罗库溴铵诱导的深度神经肌肉阻滞（NMB）后的恢复时间和对sugammadex的反应。60例患者随机（1:1）分配到亚低温组和常温组，定义为核心温度分别在34.5 - 35°C和36.5 - 37°C之间。患者先给予0.6 mg/kg的罗库溴铵，然后以7 ~ 10 μg/kg/min的剂量维持深部NMB[破伤风后计数（PTC） 1-2]。术后，用糖madex 4.0 mg/kg逆转深部NMB。主要终点是四人组（TOF）比率达到0.9的时间。给予糖madex后，即使在低温后，也能恢复适当的神经肌肉功能（TOF比≥0.9）。低温组恢复时间[平均（SD）， 171.1（62.1）秒(s)]明显慢于常温组[124.9（59.2）秒]（p = 0.005）。sugammadex没有不良反应。在轻度低温期间，Sugammadex安全可靠地逆转了深罗库溴铵诱导的NMB。低温症患者从深度NMB恢复需要额外的46 s。根据结果，我们认为这种延长的恢复时间在临床上是可以接受的。ClinicalTrials.gov标识符：NCT01965067。
Mild hypothermia may be frequently induced due to cool environments in the operating room. The study analyzed patient recovery time and response to sugammadex after a prolonged rocuronium-induced deep neuromuscular block (NMB) during mild hypothermia. Sixty patients were randomly (1:1) allocated to the mild hypothermia and normothermia groups, defined as having core temperatures between 34.5 - 35°C and 36.5 - 37°C, respectively. Patients received 0.6 mg/kg of rocuronium, followed by 7 – 10 μg/kg/min to maintain a deep NMB [post-tetanic count (PTC) 1–2]. After surgery, the deep NMB was reversed with sugammadex 4.0 mg/kg. The primary end-point was the time until the train-of-four (TOF) ratio was 0.9. The appropriate neuromuscular function (TOF ratio ≥ 0.9) was restored after sugammadex was administered, even after hypothermia. The length of recovery in the hypothermia patients [mean (SD), 171.1 (62.1) seconds (s)] was significantly slower compared with the normothermia patients [124.9 (59.2) s] (p = 0.005). There were no adverse effects from sugammadex. Sugammadex safely and securely reversed deep rocuronium-induced NMB during mild hypothermia. An additional 46 s was required for recovery from a deep NMB in hypothermia patients. Based on the results, we think this prolonged recovery time is clinically acceptable. ClinicalTrials.gov Identifier: NCT01965067.
登录
查看更多内容
影响因子：
9.8
作者：
Cammu, G.;De Kam, P. J.;Foubert, L.
通讯作者：
Foubert, L.
影响因子：
120.7
作者：
Frank, SM;Fleisher, LA;Beattie, C
通讯作者：
Beattie, C
影响因子：
5.7
作者：
Abrishami, Amir;Ho, Joyce;Chung, Frances
通讯作者：
Chung, Frances
影响因子：
2.1
作者：
Della Rocca, G.;Pompei, L.;Di Marco, P.
通讯作者：
Di Marco, P.
影响因子：
2.1
作者：
ERIKSSON, LI;VIBYMOGENSEN, J;LENNMARKEN, C
通讯作者：
LENNMARKEN, C