Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.
Volatile anaesthetics and postoperative delirium in older surgical patients-A secondary analysis of prospective cohort studies.
复制标题
DOI：
10.1111/aas.13227
复制
发表时间：
2019-01
影响因子：
2.1
通讯作者：
Perioperative Medicine Research Group
中科院分区：
文献类型：
--
作者：
Kinjo S;Lim E;Magsaysay MV;Sands LP;Leung JM;Perioperative Medicine Research Group
挥发性麻醉剂（VAs）可能与术后谵妄（POD）有关。然而，迄今为止，VAs对POD的影响尚未完全了解。本研究的目的是调查不同VA组POD的发生率。二次分析使用了一个数据库，该数据库是由接受选择性非心脏大手术的患者的前瞻性队列研究创建的。接受地氟醚、异氟醚或七氟醚全麻的患者被纳入研究。术后前两天发生的POD使用混淆评估法进行测量。本研究纳入532例患者，平均年龄73.5±6.0岁（65-96岁）。术后第1天或第2天POD的总发生率为41%。地氟醚组POD的发生率高于异氟醚组（优势比=3.35,95% CI= 1.54-7.28）。七氟醚组与异氟醚组、地氟醚组POD发生率比较，差异无统计学意义。每个VA对术后认知的影响可能不同。采用前瞻性随机方法的进一步研究是必要的，以确定麻醉类型或管理是否影响术后谵妄的发生。
Volatile Anaesthetics (VAs) may be associated with postoperative delirium (POD). However, to date, the effects of VAs on POD are not completely understood. The objective of this study was to investigate the incidence of POD in different VA groups. A secondary analysis was conducted using a database created from prospective cohort studies in patients who underwent elective major non-cardiac surgery. Patients who received general anaesthesia with desflurane, isoflurane or sevoflurane were included in the study. POD occurring on either of the first two postoperative days was measured using the Confusion Assessment Method. Five hundred and thirty two patients were included in this study, with a mean age of 73.5 ± 6.0 years (range, 65–96 years). The overall incidence of POD on either postoperative day 1 or 2 was 41%. A higher incidence of POD was noted in the desflurane group compared with the isoflurane group (Odds Ratio=3.35, 95% CI=1.54–7.28). The incidence of POD between the sevoflurane and isoflurane or desflurane group were not statistically significant. Each VA may have different effects on postoperative cognition. Further studies using a prospective randomized approach will be necessary to discern whether anaesthetic type or management affects the occurrence of postoperative delirium.
登录
查看更多内容
影响因子：
8.8
作者：
Leung JM;Sands LP;Chen N;Ames C;Berven S;Bozic K;Burch S;Chou D;Covinsky K;Deviren V;Kinjo S;Kramer JH;Ries M;Tay B;Vail T;Weinstein P;Chang S;Meckler G;Newman S;Tsai T;Voss V;Youngblom E;Perioperative Medicine Research Group
通讯作者：
Perioperative Medicine Research Group
影响因子：
5.7
作者：
Fritz BA;Kalarickal PL;Maybrier HR;Muench MR;Dearth D;Chen Y;Escallier KE;Ben Abdallah A;Lin N;Avidan MS
通讯作者：
Avidan MS
影响因子：
2.4
作者：
Järvenpää, T;Rinne, JO;Kaprio, J
通讯作者：
Kaprio, J
影响因子：
5.7
作者：
Chen, XG;Zhao, MX;Norel, E
通讯作者：
Norel, E
DOI：
10.1111/j.1532-5415.2000.tb04718.x
发表时间：
2000-06-01
影响因子：
6.3
作者：
Marcantonio, ER;Flacker, JM;Resnick, NM
通讯作者：
Resnick, NM