Smartphone data during the COVID-19 pandemic can quantify behavioral changes in people with ALS.
Smartphone data during the COVID-19 pandemic can quantify behavioral changes in people with ALS.
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DOI：
10.1002/mus.27110
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发表时间：
2021-03
期刊：
影响因子：
3.4
通讯作者：
Berry JD
中科院分区：
文献类型：
--
作者：
Beukenhorst AL;Collins E;Burke KM;Rahman SM;Clapp M;Konanki SC;Paganoni S;Miller TM;Chan J;Onnela JP;Berry JD
来自智能手机传感器的被动数据可能对医疗保健研究有用。我们的目标是使用 2019 年冠状病毒病 (COVID-19) 大流行作为阳性对照，评估通过智能手机数据量化肌萎缩侧索硬化症 (ALS) 患者行为变化的能力。八名参与者使用 Beiwe 智能手机应用程序，该应用程序在 COVID-19 爆发期间被动测量他们的位置。我们使用中断时间序列来量化美国紧急状态声明对每日回家时间和每日出行距离的影响。宣布紧急状态后，每日回家时间中位数从 19.4（四分位距 [IQR]，15.4-22.0）小时增加到 23.7（IQR，22.2-24.0）小时，中位出行距离从 42（IQR，13-83）公里减少到 3.7（IQR，1.5-10.3）公里。功能能力最低的参与者更早改变行为。在紧急状态之前和之后，与功能能力最高的参与者相比，该参与者呆在家里的时间更多，出行的时间更少。我们提供的证据表明，基于智能手机的数字表型分析可以量化 ALS 患者的行为。尽管参与者在基线时花费了大量时间在家中，但 COVID-19 紧急状态声明进一步减少了他们的活动能力。鉴于参与者每天在家的时间较多，他们接触 COVID-19 的机会可能少于一般人群。
Passive data from smartphone sensors may be useful for health‐care research. Our aim was to use the coronavirus disease‐2019 (COVID‐19) pandemic as a positive control to assess the ability to quantify behavioral changes in people with amyotrophic lateral sclerosis (ALS) from smartphone data. Eight participants used the Beiwe smartphone application, which passively measured their location during the COVID‐19 outbreak. We used an interrupted time series to quantify the effect of the US state of emergency declaration on daily home time and daily distance traveled. After the state of emergency declaration, median daily home time increased from 19.4 (interquartile range [IQR], 15.4‐22.0) hours to 23.7 (IQR, 22.2‐24.0) hours and median distance traveled decreased from 42 (IQR, 13‐83) km to 3.7 (IQR, 1.5‐10.3) km. The participant with the lowest functional ability changed behavior earlier. This participant stayed at home more and traveled less than the participant with highest functional ability, both before and after the state of emergency. We provide evidence that smartphone‐based digital phenotyping can quantify the behavior of people with ALS. Although participants spent large amounts of time at home at baseline, the COVID‐19 state of emergency declaration reduced their mobility further. Given participants' high level of daily home time, it is possible that their exposure to COVID‐19 could be less than that of the general population.
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