Modifying and reacting to the environmental pH can drive bacterial interactions.
Modifying and reacting to the environmental pH can drive bacterial interactions.
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改变环境 pH 值并对其做出反应可以促进细菌相互作用。
DOI：
10.1371/journal.pbio.2004248
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发表时间：
2018-03
期刊：
影响因子：
9.8
通讯作者：
Gore J
中科院分区：
文献类型：
--
作者：
Ratzke C;Gore J
微生物通常存在于由无数不同但相互作用的物种组成的群落中。这些相互作用通常通过环境改变来介导;微生物通过占用资源和排泄代谢物来改变环境，这影响了它们自身和其他微生物的生长。我们在这里展示了微生物改变其环境并对其做出反应的方式，这些方式设置了单物种种群内以及不同物种之间的相互作用。我们通过实验发现，这些pH值的变化会产生反馈回路，可以决定细菌种群的命运;它们可以促进或抑制生长，在极端情况下会导致细菌种群的灭绝。了解单个物种如何改变pH值并对这些变化做出反应，使我们能够估计它们的成对相互作用结果。这些相互作用导致了一组通用的相互作用模式双稳态，连续增长，延长自杀，稳定，这可能是独立的环境参数被修改，从而可能在不同的微生物系统中重新出现。微生物通常与许多其他物种一起生活在复杂的群落中。这些微生物群落对我们非常重要，因为它们也生活在我们的身体内和身体上，可以决定我们的健康和福祉。这些群落的组成和功能，例如谁是这样一个群落的一部分，谁被排除在外，是由微生物之间的相互作用决定的。这些微生物相互作用可以由许多不同的因素驱动，例如资源竞争或毒素产生。尽管这些因素都不同，但相互作用通常是通过环境介导的;微生物改变环境，它们和其他微生物必须生活在这个新环境中。我们在这里表明，通过了解微生物如何变化和对环境的反应，有可能理解甚至预测它们的相互作用。我们相信，这种思考微生物相互作用的方式将有助于更好地理解对我们的福祉如此重要的更复杂的社区。
Microbes usually exist in communities consisting of myriad different but interacting species. These interactions are typically mediated through environmental modifications; microbes change the environment by taking up resources and excreting metabolites, which affects the growth of both themselves and also other microbes. We show here that the way microbes modify their environment and react to it sets the interactions within single-species populations and also between different species. A very common environmental modification is a change of the environmental pH. We find experimentally that these pH changes create feedback loops that can determine the fate of bacterial populations; they can either facilitate or inhibit growth, and in extreme cases will cause extinction of the bacterial population. Understanding how single species change the pH and react to these changes allowed us to estimate their pairwise interaction outcomes. Those interactions lead to a set of generic interaction motifs—bistability, successive growth, extended suicide, and stabilization—that may be independent of which environmental parameter is modified and thus may reoccur in different microbial systems. Microbes typically live alongside many other species in complex communities. These microbial communities are very important for us because they also live in and on our bodies and can determine our health and well-being. The composition and function of these communities, such as who is part of such a community and who is excluded, are decided by the interactions between the microbes. These microbial interactions can be driven by many different factors such as resource competition or toxin production. Although these factors are all different, the interactions are typically mediated through the environment; the microbes modify the environment, and they and other microbes have to live in this new environment. We show here that by understanding how microbes change and react to the environment, it is possible to understand and even predict their interactions. We believe that this way of thinking about microbial interactions will lead to a better understanding of more complex communities that are so important for our well-being.
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DOI：
10.1098/rspb.2004.2916
发表时间：
2005-01-07
影响因子：
4.7
作者：
Dugatkin, LA;Perlin, M;Atlas, R
通讯作者：
Atlas, R
DOI：
10.1038/nrmicro2259
发表时间：
2010-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.2
作者：
Drescher, Knut;Nadell, Carey D.;Stone, Howard A.;Wingreen, Ned S.;Bassler, Bonnie L.
通讯作者：
Bassler, Bonnie L.
影响因子：
16.8
作者：
Courchamp, F;Clutton-Brock, T;Grenfell, B
通讯作者：
Grenfell, B
影响因子：
4.8
作者：
HINDELL, MA
通讯作者：
HINDELL, MA