Solutions to the public goods dilemma in bacterial biofilms.
Solutions to the public goods dilemma in bacterial biofilms.
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DOI：
10.1016/j.cub.2013.10.030
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发表时间：
2014-01-06
期刊：
影响因子：
9.2
通讯作者：
Bassler, Bonnie L.
中科院分区：
文献类型：
--
作者：
Drescher, Knut;Nadell, Carey D.;Stone, Howard A.;Wingreen, Ned S.;Bassler, Bonnie L.
细菌经常生活在人口密集的表面群落中，称为生物膜。生物膜驻留细胞依靠细胞外物质的分泌来构建其群落并从环境中捕获营养物质。一些分泌因子表现为合作公共产品：它们可以被非生产细胞利用。产生公共利益的细菌如何避免在生物膜环境中被利用，目前尚不清楚。霍乱弧菌分泌胞外酶来消化其主要食物来源固体聚合物甲壳素，通过对霍乱弧菌的实验，我们发现公共物品困境可以通过两种截然不同的机制来解决：细胞可以产生厚厚的生物膜，将物品限制在生产者手中，或者流体流动可以去除甲壳素消化的可溶性产物，从而阻止非生产者进入。这两个过程通过限制酶分泌细胞为邻居提供利益的距离而统一，从而为附近的克隆人带来优先利益，并允许亲缘选择有利于公共产品的生产。我们的结果证明了自然栖息地的物理条件可以与细菌生理学相互作用以促进合作进化的新机制。
Bacteria frequently live in densely populated surface-bound communities, termed biofilms. Biofilm-dwelling cells rely on secretion of extracellular substances to construct their communities and to capture nutrients from the environment. Some secreted factors behave as cooperative public goods: they can be exploited by non-producing cells. The means by which public-good-producing bacteria avert exploitation in biofilm environments are largely unknown. Using experiments with Vibrio cholerae, which secretes extracellular enzymes to digest its primary food source, the solid polymer chitin, we show that the public goods dilemma may be solved by two very different mechanisms: cells can produce thick biofilms that confine the goods to producers, or fluid flow can remove soluble products of chitin digestion, denying access to non-producers. Both processes are unified by limiting the distance over which enzyme-secreting cells provide benefits to neighbors, resulting in preferential benefit to nearby clonemates and allowing kin selection to favor public good production. Our results demonstrate new mechanisms by which the physical conditions of natural habitats can interact with bacterial physiology to promote the evolution of cooperation.
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DOI：
10.1073/pnas.1300321110
发表时间：
2013-03-12
影响因子：
11.1
作者：
Drescher, Knut;Shen, Yi;Stone, Howard A.
通讯作者：
Stone, Howard A.
影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
2.9
作者：
Ross-Gillespie, Adin;Gardner, Andy;Griffin, Ashleigh S.
通讯作者：
Griffin, Ashleigh S.
影响因子：
56.9
作者：
Chuang, John S.;Rivoire, Olivier;Leibler, Stanislas
通讯作者：
Leibler, Stanislas
细菌生物膜中的法定感应和作弊。
DOI：
10.1098/rspb.2012.1976
发表时间：
2012-12-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Popat R;Crusz SA;Messina M;Williams P;West SA;Diggle SP
通讯作者：
Diggle SP