Diagnosis and management of resistant hypertension.

Diagnosis and management of resistant hypertension.
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顽固性高血压的诊断和治疗。

DOI:
10.1136/heartjnl-2015-308297
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发表时间:
2017
期刊:
Heart (British Cardiac Society)
影响因子:
--
通讯作者:
Sheppard JP
Sheppard JP
中科院分区:
--
文献类型:
--
作者:
Sheppard JP

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高血压(高血压)是心血管疾病最重要的风险因素之一,1 2是全球发病率和死亡率的重要原因。3最近来自发达国家的调查显示,高血压的患病率为20%至30%,其中51%至80%接受治疗,但只有27%至66%的血压得到充分控制。[4]对治疗无反应的未控制高血压患者的一个子集被称为耐药高血压患者。本文将描述如何定义顽固性高血压,其患病率和预后,在常规实践中有效诊断的方法,以及有效管理诊断为该病的患者的策略。顽固性高血压的定义顽固性高血压通常定义为在用三种或更多种抗高血压药物治疗后未控制的门诊血压(> 140/90 mm Hg)。5在英国,国家健康与护理卓越研究所(NICE)指南规定,这三种药物应包括最佳剂量的ACE抑制剂(或血管紧张素受体阻滞剂)、钙通道阻滞剂和利尿剂。6然而,有一些情况可以排除顽固性高血压,在正式诊断之前必须排除这些情况。所谓的“假性抵抗性”高血压可能是由不良的临床血压测量技术、患者不依从处方药物、患者对某些抗高血压药物不耐受和白色大衣高血压(其中血压在临床上看起来很高,但在办公室外通过家庭或门诊测量得到控制)引起的。5
High blood pressure (hypertension) is one of the most important risk factors for cardiovascular disease, 1 2 which is a significant cause of morbidity and mortality worldwide. 3 Recent surveys from developed countries suggest that the prevalence of hypertension ranges from 20% to 30%, with 51%–80% receiving treatment but only 27%–66% with adequate blood pressure control. 4 One subset of uncontrolled hypertensives who do not respond to treatment are known as resistant hypertensives. This article will describe how resistant hypertension is defined, its prevalence and prognosis, methods to diagnose it effectively in routine practice and strategies to effectively manage patients diagnosed with the condition. definition of resistant hypertensionResistant hypertension is generally defined as uncontrolled clinic blood pressure (> 140/90 mm Hg) after treatment with three or more antihypertensives. 5 In the UK, National Institute for Health and Care Excellence (NICE) guidelines specify that these three should include optimal doses of an ACE inhibitor (or an angiotensin receptor blocker), a calcium channel blocker and a diuretic. 6 However, there are some circumstances which preclude resistant hypertension, which must be ruled out before a formal diagnosis can be made. The so-called ‘pseudoresistant’hypertension can be caused by poor clinic blood pressure measurement technique, patient non-adherence to prescribed medication, patient intolerance to certain antihypertensive medications and white coat hypertension (where blood pressure appears high in the clinic but is controlled out-of-the-office on home or ambulatory measurements). 5
高血压新闻屏幕:螺内酯与可乐定作为顽固性高血压的第四种药物疗法 Œ ReHOT 随机研究(顽固性高血压最佳治疗)
DOI: --
发表时间: 2020
期刊:
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