Protective effect of huoxiang zhengqi oral liquid on intestinal mucosal mechanical barrier of rats with postinfectious irritable bowel syndrome induced by acetic Acid.

Protective effect of huoxiang zhengqi oral liquid on intestinal mucosal mechanical barrier of rats with postinfectious irritable bowel syndrome induced by acetic Acid.
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DOI:
10.1155/2014/218383
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发表时间:
2014
期刊:
Evidence-based complementary and alternative medicine : eCAM
影响因子:
--
通讯作者:
Hu JL
Hu JL
中科院分区:
其他
文献类型:
--
作者:
Liu Y;Liu W;Peng QX;Peng JL;Yu LZ;Hu JL

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本研究采用乙酸诱导的腹泻型肠易激综合征(PI - IBS)大鼠模型,研究和中启膈口服液在修复结肠上皮屏障和降低肠道通透性方面的作用。通过检测结肠组织病理形态、上皮超微结构、血清中二胺氧化酶(DAO)活性以及紧密连接蛋白 - 1(ZO - 1)和闭合蛋白(occludin)的蛋白表达,探讨和中启膈口服液对肠黏膜屏障的保护作用机制,进而为其用于防治PI - IBS提供实验依据。
In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.
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