Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma.
Glucose Metabolism and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous Cell Carcinoma.
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DOI：
10.1371/journal.pone.0166236
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Shirato H
中科院分区：
文献类型：
--
作者：
Fujima N;Sakashita T;Homma A;Hirata K;Shiga T;Kudo K;Shirato H
目的探讨头颈部鳞状细胞癌（HNSCC）糖代谢与肿瘤血流量（TBF）的关系。我们回顾性分析了57例HNSCC患者。通过18F-氟脱氧葡萄糖正电子发射断层扫描获得的最大和平均标准化摄取值（SUVmax和SUVmean）评估肿瘤葡萄糖代谢。TBF值通过使用3特斯拉MRI的动脉自旋标记获得。在整个系列中以及按T分期（T1-T3和T4组）和肿瘤位置（咽/口腔和鼻窦组）划分的患者中评估SUV和TBF之间的相关性。计算Pearson相关系数以获得显著相关性。检测到显著相关性：晚期T分期组呈负相关（TBF和SUV max：r，-0.61，SUV mean：r，-0.62），非晚期T分期咽/口腔组呈正相关（TBF与SUVmax：r，0.70，SUVmean：r，0.73），在晚期T期咽/口腔组中呈负相关（TBF和SUVmax：r，-0.62，SUVmean：r，-0.65），晚期T期鼻窦腔组呈负相关（TBF和SUVmax：r，-0.61，SUVmean：r，-0.65）。HNSCC中葡萄糖摄取与TBF之间的显著相关性通过T分期和肿瘤部位的划分而揭示。
To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1–T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups). Pearson’s correlation coefficients were calculated for significant correlations. Significant correlations were detected: a negative correlation in the advanced T-stage group (TBF and SUV max: r, −0.61, SUVmean: r, −0.62), a positive correlation in the non-advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, 0.70, SUVmean: r, 0.73), a negative correlation in the advanced T-stage pharynx/oral cavity group (TBF and SUVmax: r, −0.62, SUVmean: r, −0.65), and a negative correlation in the advanced T-stage sinonasal cavity group (TBF and SUVmax: r, −0.61, SUVmean: r, −0.65). Significant correlations between glucose uptake and TBF in HNSCC were revealed by the division of T-stage and tumor location.
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影响因子：
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