Clinical significance of erythropoietin receptor expression in oral squamous cell carcinoma.
Clinical significance of erythropoietin receptor expression in oral squamous cell carcinoma.
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DOI：
10.1186/1471-2407-12-194
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发表时间：
2012-05-28
期刊：
影响因子：
3.8
通讯作者：
Chien CY
中科院分区：
文献类型：
--
作者：
Lin YT;Chuang HC;Chen CH;Armas GL;Chen HK;Fang FM;Huang CC;Chien CY
低分化肿瘤对放射和化学疗法是难治的。头颈部癌中缺氧相关生物标志物的高表达与预后不良相关。本研究旨在探讨促红细胞生成素受体（EPOR）在口腔鳞状细胞癌（OSCC）中的表达及其临床病理意义。该研究纳入了256名在1996年10月至2005年8月期间接受初次手术切除治疗的OSCC患者，这些患者之前没有接受过放疗和/或化疗。从临床记录和病理报告中获得临床病理信息，包括性别、年龄、T分类、N分类和TNM分期。采用定量逆转录聚合酶链反应（Q-RT-PCR）、免疫印迹和免疫组织化学方法检测EPOR mRNA和蛋白的表达水平。我们发现EPOR在口腔鳞状细胞癌组织中呈高表达。该研究包括17名女性和239名男性，平均年龄为50.9岁（范围，26-87岁）。平均随访时间为67个月（范围，2-171个月）。EPOR高表达与晚期T分期（p < 0.001）、晚期TNM分期（p < 0.001）和阳性N分期（p = 0.001）显著相关。此外，单变量分析显示，肿瘤EPOR高表达患者的5年总生存率（p = 0.0011）和5年疾病特异性生存率（p = 0.0017）低于肿瘤EPOR水平低的患者。然而，多因素分析使用考克斯的回归模型显示，只有T和N分类的5年总生存率和5年疾病特异性生存率的独立预后因素。在单因素分析中，EPOR在口腔鳞癌中的高表达与口腔鳞癌的侵袭性肿瘤行为和较差的预后相关。因此，EPOR的表达可能成为未来口腔鳞癌治疗的靶点。
Hypoxic tumors are refractory to radiation and chemotherapy. High expression of biomarkers related to hypoxia in head and neck cancer is associated with a poorer prognosis. The present study aimed to evaluate the clinicopathological significance of erythropoietin receptor (EPOR) expression in oral squamous cell carcinoma (OSCC). The study included 256 patients who underwent primary surgical resection between October 1996 and August 2005 for treatment of OSCC without previous radiotherapy and/or chemotherapy. Clinicopathological information including gender, age, T classification, N classification, and TNM stage was obtained from clinical records and pathology reports. The mRNA and protein expression levels of EPOR in OSCC specimens were evaluated by Q-RT-PCR, Western blotting and immunohistochemistry assays. We found that EPOR were overexpressed in OSCC tissues. The study included 17 women and 239 men with an average age of 50.9 years (range, 26–87 years). The mean follow-up period was 67 months (range, 2–171 months). High EPOR expression was significantly correlated with advanced T classification (p < 0.001), advanced TNM stage (p < 0.001), and positive N classification (p = 0.001). Furthermore, the univariate analysis revealed that patients with high tumor EPOR expression had a lower 5-year overall survival rate (p = 0.0011) and 5-year disease-specific survival rate (p = 0.0017) than patients who had low tumor levels of EPOR. However, the multivariate analysis using Cox’s regression model revealed that only the T and N classifications were independent prognostic factors for the 5-year overall survival and 5-year disease-specific survival rates. High EPOR expression in OSCC is associated with an aggressive tumor behavior and poorer prognosis in the univariate analysis among patients with OSCC. Thus, EPOR expression may serve as a treatment target for OSCC in the future.
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DOI：
10.1093/jnen/60.4.386
发表时间：
2001-04-01
影响因子：
3.2
作者：
Nagai, A;Nakagawa, E;Kim, SU
通讯作者：
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影响因子：
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