Impaired binding of drugs and endogenous ligands in renal diseases.
Impaired binding of drugs and endogenous ligands in renal diseases.
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肾脏疾病中药物和内源性配体的结合受损。
DOI：
10.1016/s0272-6386(83)80038-9
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Depner,TA
中科院分区：
文献类型：
--
作者：
Gulyassy,PF;Depner,TA
在过去的二十年里，透析疗法对慢性肾衰竭的经验性治疗取得了相当大的成功。肾病学家不仅可以避免终末期肾衰竭患者的某些死亡，而且还可以使许多患者恢复并保持多年的合理健康。经过最初几年的透析治疗，当生命的延长本身就代表了一个有价值的成就时，肾病学家开始更严格地检查当前透析治疗的不足之处。许多持续的主观、功能和生化紊乱的例子是显而易见的。目前透析治疗的一些不足之处，如贫血，部分原因是我们目前无法取代复杂的肾脏合成过程。关于目前治疗的一些不足之处是由于对保留的”中分子”（300- 5，000道尔顿）的去除效率低下的假设，已经有相当多的讨论。然而，支持这一假设的令人信服的数据很少。多年来，我们一直对一种不同的可能性感兴趣，即尽管进行常规透析治疗，但某些尿毒症缺陷仍然存在，这是由于有毒溶质的积累，这些溶质与血浆蛋白紧密结合，因此无法通过目前的治疗有效清除，特别是通过玻璃纸膜透析。这些保留的蛋白质结合配体已被证明取代内源性溶质，如色氨酸和胆红素，和许多药物。1-3
THE EMPIRICAL TREATMENT of chronic renal failure with dialysis therapies has achieved considerable success during the past two decades. Not only can the nephrologist avert certain death in patients with terminal renal failure, but he can also enable many patients to return to and maintain reasonable health over many years. After the initial years of dialysis therapy, when prolongation of life alone represented a worthy achievement, nephrologists began to examine more critically the inadequacies of current dialysis treatment. Many examples of persisting subjective, functional, and biochemical disturbances were readily apparent. Some of the inadequacies of current dialysis therapy, eg, anemia, result in part from our current inability to replace complex renal synthetic processes. There has been considerable discussion about the hypothesis that some of the inadequacies of present therapy are due to inefficient removal of retained" middle molecules"(300-5,000 daltons). Convincing data in support of this hypothesis, however, are meager. For a number of years, we have been interested in a different possibility-that certain uremic defects that persist despite regular dialysis therapy result from the accumulation of toxic solutes, which are strongly bound to plasma proteins and, therefore, cannot be removed efficiently by current treatments, especially by dialysis across cellophane membranes. These retained protein-bound ligands have been shown to displace both endogenous solutes, such as tryptophan and bilirubin, and many drugs. 1-3
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[35-S]呋塞米的肾分泌和白蛋白结合抑制。
影响因子：
--
作者：
R. H. Bowman
通讯作者：
R. H. Bowman
正常血浆和透析前后尿毒症血浆中马尿酸的结合。
影响因子：
2.5
作者：
Peter C. Farrell;Frank A. Gotch;John H. Peters;Bernard J. Berridge, jr.;Maryann Lam
通讯作者：
Maryann Lam
血浆蛋白置换相互作用很少具有临床意义。
影响因子：
3.1
作者：
E. Sellers
通讯作者：
E. Sellers
慢性肾功能衰竭和血液透析对二氟尼血浆蛋白结合的影响
影响因子：
6.7
作者：
R. Verbeeck;P. De Schepper
通讯作者：
P. De Schepper
血液透析期间奎尼丁血浆蛋白结合减少
DOI：
--
发表时间：
1981
期刊：
Clinical pharmacology and therapy
影响因子：
--
作者：
K. Kessler;G. Perez
通讯作者：
G. Perez