Crosslinkable fluorophenoxy-substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility.
Crosslinkable fluorophenoxy-substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility.
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DOI：
10.1002/jbm.b.35252
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发表时间：
2023-08
影响因子：
3.4
通讯作者：
Xu, Li-Chong
中科院分区：
文献类型：
--
作者：
Alwine, Shelby;Chen, Chen;Shen, Lihui;Allcock, Harry R.;Siedlecki, Christopher A.;Xu, Li-Chong
关键词：
生物材料相关微生物感染是与医疗器械中生物材料使用相关的最常见和最严重的并发症之一。在以前的研究中，我们开发了新的氟化聚磷腈，聚[双（八氟戊氧基）磷腈]（OFP）和可交联OFP（X-OFP），并证明了抑制细菌粘附和生物膜形成，从而控制微生物感染。在这项研究中，两个额外的氟化聚磷腈（PP，定义为LS 02和LS 03）与氟苯氧基取代的侧基，4-氟苯氧基和4-（三氟甲基）苯氧基，分别基于X-OFP的一般结构，合成并应用于不锈钢涂层。发现氟苯氧基基团与PP的P-N主链的连接增加了表面刚度，并显著降低了葡萄球菌细菌粘附并抑制了生物膜形成。与OFP、我们先前的X-OFP或聚[双（三氟乙氧基）磷腈]（TFE）相比，它还显著降低了微生物感染。生物膜实验表明，新合成的PP LS 02和LS 03在长达28天内没有生物膜。血浆凝固和血小板粘附/活化实验也证明了含有氟苯氧基侧基的新PP具有血液相容性。含有氟苯氧基取代的侧基的新型可交联氟化PP的开发提供了用于医疗器械的新一代聚磷腈材料，其具有改善的抗微生物感染和血栓形成性。
Biomaterial-associated microbial infection is one of the most frequent and severe complications associated with the use of biomaterials in medical devices. In previous studies, we developed new fluorinated polyphosphazenes, poly[bis(octafluoropentoxy) phosphazene] (OFP) and crosslinkable OFP (X-OFP), and demonstrated the inhibition of bacterial adhesion and biofilm formation, thereby controlling microbial infection. In this study, two additional fluorinated polyphosphazenes (PPs, defined as LS02 and LS03) with fluorophenoxy-substituted side groups, 4-fluorophenoxy and 4-(trifluoromethyl)phenoxy, respectively, based on X-OFP general structure, were synthesized and applied as coatings on stainless steel. The linkage of fluorophenoxy groups to the P-N backbone of PPs was found to increase the surface stiffness and significantly reduced Staphylococcus bacterial adhesion and inhibited biofilm formation. It also significantly reduced microbial infection compared to OFP, our prior X-OFPs or poly[bis(trifluoroethoxy) phosphazene] (TFE). The biofilm experiments show that the newly synthesized PPs LS02 and LS03 are biofilm free up to 28 days. Plasma coagulation and platelet adhesion/activation experiments also demonstrated that new PPs containing fluorophenoxy side groups are hemocompatible. The development of new crosslinkable fluorinated PPs containing fluorophenoxy-substituted side groups provides a new generation of polyphosphazene materials for medical devices with improved resistance to microbial infections and thrombosis formation.
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影响因子：
4
作者：
Allcock, Harry R.
通讯作者：
Allcock, Harry R.
影响因子：
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作者：
Allcock, Harry R.;Chen, Chen
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DOI：
10.1007/s40883-019-00097-3
发表时间：
2019-12-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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