Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.
Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.
复制标题
DOI：
10.1038/s41525-021-00253-1
复制
发表时间：
2021-11-01
影响因子：
5.3
通讯作者：
O'Donnell PH
中科院分区：
文献类型：
--
作者：
Saulsberry L;Danahey K;Borden BA;Lipschultz E;Traore M;Ratain MJ;Meltzer DO;O'Donnell PH
在一个机构药物基因组学实施计划中，我们调查了463名完成抢先药物基因组学检测的门诊患者，其遗传结果可供提供者指导药物治疗。我们比较了自我报告的白色和黑人患者的观点和经验，包括教育水平作为分析的协变量。黑人患者对他们的提供者是否做出个性化治疗决定不太有信心，并且绝大多数人希望他们的遗传信息在临床护理中发挥更大的作用。两组同样报告说，提供者询问他们对药物变化的意见，但白色患者更有可能（59%对49%，P = 0.005）与提供者讨论个人/遗传构成对药物反应的影响，黑人患者报告说，发起此类讨论的频率要低得多（4%对15%，P = 0.037）。机会存在，以加强沟通，与代表性不足的病人周围的个性化护理。量身定制的沟通策略和开发支持工具，在不同的医疗环境中使用，可以促进药物遗传学指导的药物治疗，公平地造福少数患者群体。
Within an institutional pharmacogenomics implementation program, we surveyed 463 outpatients completing preemptive pharmacogenomic testing whose genetic results were available to providers for guiding medication treatment. We compared views and experiences from self-reported White and Black patients, including education level as a covariate across analyses. Black patients were less confident about whether their providers made personalized treatment decisions, and overwhelmingly wanted a greater role for their genetic information in clinical care. Both groups similarly reported that providers asked their opinions regarding medication changes, but White patients were more likely (59% vs. 49%, P = 0.005) to discuss the impact of personal/genetic makeup on medication response with providers, and Black patients reported initiating such discussions much less frequently (4% vs. 15%, P = 0.037). Opportunities exist for enhanced communication with underrepresented patients around personalized care. Tailored communication strategies and development of support tools employed in diverse healthcare settings may facilitate pharmacogenomically guided medication treatment that equitably benefits minority patient populations.
登录
查看更多内容
影响因子：
9.7
作者：
Anthony, Denise L.;Campos-Castillo, Celeste;Lim, Paulina S.
通讯作者：
Lim, Paulina S.
影响因子：
4.4
作者：
Kaphingst, Kimberly A.;Blanchard, Melvin;Goodman, Melody S.
通讯作者：
Goodman, Melody S.
影响因子：
1.7
作者：
Diaz, V. A.;Mainous, A. G., III;Wilson, D.
通讯作者：
Wilson, D.
影响因子：
8.8
作者：
Condit, C;Templeton, A;Harris, TM
通讯作者：
Harris, TM
影响因子：
1.7
作者：
De Marco, M.
通讯作者：
De Marco, M.