Crosstalk Between Polygonatum kingianum, the miRNA, and Gut Microbiota in the Regulation of Lipid Metabolism.
Crosstalk Between Polygonatum kingianum, the miRNA, and Gut Microbiota in the Regulation of Lipid Metabolism.
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黄精、miRNA 和肠道微生物群在脂质代谢调节中的相互作用。
DOI：
10.3389/fphar.2021.740528
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发表时间：
2021
影响因子：
5.6
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Dong J;Gu W;Yang X;Zeng L;Wang X;Mu J;Wang Y;Li F;Yang M;Yu J
目的：黄精是一种用于多种中药制剂的草药。在脂质代谢异常的大鼠模型中，P. kingianum 的多糖部分可以通过下调 miR-122 来降低胰岛素抵抗并恢复肠道微生物群。本研究的目的是进一步阐明 P. kingianum 对脂质代谢的影响，以及特定 miRNA 和肠道微生物群的作用。 主要发现：P. kingianum 的施用显着改变了 29 种肠道微生物和 27 种差异表达 miRNA (DEM) 的丰度。鉴定出几种与脂质代谢密切相关的异常表达的 miRNA，其中一些与特定的肠道微生物群相关。尤其是 MiR-484 被确定为参与 P. kingianum 治疗效果的核心因素。我们假设 miR-484-Bacteroides/Roseburia 轴充当连接整个 miRNA-肠道微生物群网络的重要桥梁枢纽。此外，我们观察到 Parabacteroides 和 Bacillus 与多种 miRNA 显着相关，包括 miR-484、miR-122-5p、miR-184 和 miR-378b。 摘要：P. kingianum 通过靶向关键 miRNA 网络和肠道微生物群来缓解脂质代谢紊乱。
Objectives: Polygonatum kingianum is a medicinal herb used in various traditional Chinese medicine formulations. The polysaccharide fraction of P. kingianum can reduce insulin resistance and restore the gut microbiota in a rat model of aberrant lipid metabolism by down regulating miR-122. The aim of this study was to further elucidate the effect of P. kingianum on lipid metabolism, and the roles of specific miRNAs and the gut microbiota. Key findings: P. kingianum administration significantly altered the abundance of 29 gut microbes and 27 differentially expressed miRNAs (DEMs). Several aberrantly expressed miRNAs closely related to lipid metabolism were identified, of which some were associated with specific gut microbiota. MiR-484 in particular was identified as the core factor involved in the therapeutic effects of P. kingianum. We hypothesize that the miR-484-Bacteroides/Roseburia axis acts as an important bridge hub that connects the entire miRNA-gut microbiota network. In addition, we observed that Parabacteroides and Bacillus correlated significantly with several miRNAs, including miR-484, miR-122-5p, miR-184 and miR-378b. Summary: P. kingianum alleviates lipid metabolism disorder by targeting the network of key miRNAs and the gut microbiota.
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DOI：
10.1016/j.jnutbio.2017.02.003
发表时间：
2017-05
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Sud N;Zhang H;Pan K;Cheng X;Cui J;Su Q
通讯作者：
Su Q
影响因子：
30.3
作者：
Liu S;da Cunha AP;Rezende RM;Cialic R;Wei Z;Bry L;Comstock LE;Gandhi R;Weiner HL
通讯作者：
Weiner HL
影响因子：
4.1
作者：
Ge Q;Brichard S;Yi X;Li Q
通讯作者：
Li Q
影响因子：
4.4
作者：
Wei R;Qiu D;Wilson IW;Zhao H;Lu S;Miao J;Feng S;Bai L;Wu Q;Tu D;Ma X;Tang Q
通讯作者：
Tang Q
影响因子：
8.8
作者：
Elhanati, Sivan;Ben-Hamo, Rotem;Cohen, Haim Y.
通讯作者：
Cohen, Haim Y.