microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome.
microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome.
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DOI：
10.1155/2014/987285
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发表时间：
2014
影响因子：
4.1
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Ge Q;Brichard S;Yi X;Li Q
肥胖与代谢综合征(MS)密切相关。众所周知，肥胖诱导的慢性炎症在MS的发病机制中起着基础性作用。白色脂肪组织(AT)是肥胖相关炎症的起始和加重的主要部位。探讨白色AT的炎症机制，重新调整白色AT的免疫平衡可能对MS的治疗至关重要。目前已提出了几种重要的分子机制来介导白色AT的炎症，包括缺氧、内质网应激、脂毒性和代谢性内毒素血症。最近，越来越多的证据支持miRNAs作为一种新的重要的炎症介质，通过调节获得性免疫和先天免疫来发挥作用。这篇综述将集中于miRNAs在肥胖的白色AT炎症中的意义，并将强调miRNAs作为治疗干预MS的靶点的潜力以及miRNA靶向治疗中存在的挑战。
Obesity is associated closely with the metabolic syndrome (MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
5.8
作者：
Alexander R;Lodish H;Sun L
通讯作者：
Sun L
脂肪组织 microRNA 作为人类肥胖中 CCL2 产生的调节因子。
影响因子：
7.7
作者：
Arner E;Mejhert N;Kulyté A;Balwierz PJ;Pachkov M;Cormont M;Lorente-Cebrián S;Ehrlund A;Laurencikiene J;Hedén P;Dahlman-Wright K;Tanti JF;Hayashizaki Y;Rydén M;Dahlman I;van Nimwegen E;Daub CO;Arner P
通讯作者：
Arner P
影响因子：
--
作者：
FAUST, IM;JOHNSON, PR;HIRSCH, J
通讯作者：
HIRSCH, J
影响因子：
--
作者：
Bernstein, LE;Berry, J;Grinspoon, SK
通讯作者：
Grinspoon, SK