Repeat Sentinel Lymph Node Biopsy for Ipsilateral Breast Tumor Recurrence After Breast Conserving Surgery With Sentinel Lymph Node Biopsy: Pooled Analysis Using Data From a Systematic Review and Two Institutions.
Repeat Sentinel Lymph Node Biopsy for Ipsilateral Breast Tumor Recurrence After Breast Conserving Surgery With Sentinel Lymph Node Biopsy: Pooled Analysis Using Data From a Systematic Review and Two Institutions.
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DOI：
10.3389/fonc.2020.518568
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发表时间：
2020
影响因子：
4.7
通讯作者：
Jeong J
中科院分区：
文献类型：
--
作者：
Yoon CI;Ahn SG;Kim D;Choi JE;Bae SJ;Cha CH;Park S;Jeong J
摘要：局部复发乳腺癌腋窝分期的最佳手术方法仍有争议。我们从检出率（IR）和假阴性率（FNR）两方面对保乳手术（BCS）后同侧乳腺肿瘤复发（IBTR）患者进行前哨淋巴结活检（reSLNB）的可靠性进行了评估。为了解决FNR，我们确定了reSLNB后接受序贯腋窝淋巴结清扫（ALND）的患者。方法：系统检索PubMed、EMBASE和Cochrane图书馆，从文章中识别患者水平的数据。我们检索了因原发性乳腺癌行BCS合并SLNB以及因局部复发而行reSLNB后序贯ALND的患者的资料。两家机构的患者数据也按照相同的标准进行了识别。结果：共获得同行评议出版物197篇，其中20篇纳入符合入选标准的患者。收集了464例患者的数据。从这两个机构中，确定了31名患者。共纳入495例患者。reSLNB的IR为71.9%（356/495）。为了解决reSLNB的FNR，我们确定了171例reSLNB后发生ALND的患者。reSLNB的FNR和准确率分别为9.4%（5/53）和97.1%（165/170）。结论：我们的汇总数据分析显示，reSLNB的FNR低于10%，表明该手术是IBTR患者行BCS后可靠的腋窝手术。
Introduction: Best surgical approach of axillary staging remains controversial in locally recurrent breast cancer. We evaluated the reliability of repeat sentinel lymph node biopsy (reSLNB) in patients with ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) with sentinel lymph node biopsy (SLNB) in terms of identification rate (IR) and false negative rate (FNR). To address the FNR, we identified patients who underwent sequential axillary lymph node dissection (ALND) after reSLNB. Methods: A systematic search of PubMed, EMBASE, and Cochrane Library were conducted to identify patient-level data from articles. We searched for data of patients who underwent BCS with SLNB for primary breast cancer and who underwent sequential ALND after reSLNB due to local recurrence. Patients data was also identified by the same criteria at two institutions. Results: In total, 197 peer-reviewed publications were obtained, of which 20 included patients who met the eligibility criteria. Data from 464 patients were collected. From the two institutions, 31 patients were identified. A total of 495 patients were pooled. The IR of reSLNB was 71.9% (356/495). To address the FNR of reSLNB, 171 patients who underwent ALND after reSLNB were identified. The FNR and accuracy of reSLNB were 9.4% (5/53) and 97.1% (165/170), respectively. Conclusion: Our pooled data analysis showed that the FNR of reSLNB is lower than 10%, indicating that this operation is a reliable axillary surgery in patients with IBTR after they underwent BCS.
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影响因子：
120.7
作者：
Boughey, Judy C.;Suman, Vera J.;Mittendorf, Elizabeth A.;Ahrendt, Gretchen M.;Wilke, Lee G.;Taback, Bret;Leitch, A. Marilyn;Kuerer, Henry M.;Bowling, Monet;Flippo-Morton, Teresa S.;Byrd, David R.;Ollila, David W.;Julian, Thomas B.;McLaughlin, Sarah A.;McCall, Linda;Symmans, W. Fraser;Le-Petross, Huong T.;Haffty, Bruce G.;Buchholz, Thomas A.;Nelson, Heidi;Hunt, Kelly K.
通讯作者：
Hunt, Kelly K.
影响因子：
2.5
作者：
Ashikaga, Takamaru;Krag, David N.;Land, Stephanie R.;Julian, Thomas B.;Anderson, Stewart J.;Brown, Ann M.;Skelly, Joan M.;Harlow, Seth P.;Weaver, Donald L.;Mamounas, Eleftherios P.;Costantino, Joseph P.;Wolmark, Norman
通讯作者：
Wolmark, Norman
影响因子：
3.8
作者：
Koizumi, M.;Koyama, M.;Saga, T.
通讯作者：
Saga, T.
影响因子：
45.3
作者：
Boileau, Jean-Francois;Poirier, Brigitte;Robidoux, Andre
通讯作者：
Robidoux, Andre
影响因子：
2.5
作者：
Karanlik, Hasan;Ozgur, Ilker;Gulluoglu, Bahadir M.
通讯作者：
Gulluoglu, Bahadir M.