Restoration of normal hematopoiesis by bone marrow ablation and allogeneic marrow transplantation in a case of Hodgkin's disease therapy-related preleukemia.
Restoration of normal hematopoiesis by bone marrow ablation and allogeneic marrow transplantation in a case of Hodgkin's disease therapy-related preleukemia.
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通过骨髓消融和同种异体骨髓移植在一例霍奇金病治疗相关的白血病前期恢复正常造血功能。
DOI：
10.1182/blood.v61.6.1275.bloodjournal6161275
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发表时间：
1983
期刊：
影响因子：
20.3
通讯作者：
E. Tawil
中科院分区：
文献类型：
--
作者：
M. Gyger;C. Perreault;J. Boileau;J. Aymard;Y. Bonny;M. Lacombe;R. Lavallée;G. D'Angelo;E. Tawil
Therapy-related leukemias are generally preceded by a preleukemic phase of several months duration, characterized by pancytopenia, abnormal bone marrow findings, and nonrandom chromosomal abnormalities in almost all cases. No specific therapeutic guidelines are recommended in this preleukemic phase or any other type of preleukemia; aggressive combination chemotherapy is usually withheld until the full expression of leukemia. A 22-yr-old man with therapy-related preleukemia following treatment of Hodgkin's disease received as primary treatment ablative chemotherapy followed by marrow transplantation from his histocompatible sister. At day 316, the patient is still in complete bone marrow recovery with a normal donor karyotype. In the light of the very poor results obtained with conventional chemotherapy regimens once the leukemic phase is established, we suggest that bone marrow transplantation, if undertaken before leukemic conversion, may be the treatment of choice in young adults with therapy-related preleukemia.
与化疗药物相关的第二种恶性肿瘤。
影响因子：
4
作者：
Kyle,RA
通讯作者：
Kyle,RA
影响因子：
3.1
作者：
J. Rowley;H. Golomb;J. Vardiman
通讯作者：
J. Rowley;H. Golomb;J. Vardiman
影响因子：
20.3
作者：
K. Rai;J. Holland;O. Glidewell;V. Weinberg;K. Brunner;JP Obrecht;H. Preisler;IW Nawabi;D. Pr
通讯作者：
K. Rai;J. Holland;O. Glidewell;V. Weinberg;K. Brunner;JP Obrecht;H. Preisler;IW Nawabi;D. Pr