Serum Detection of Anti-thyroid Peroxidase and Anti-thyroglobulin Antibodies in Chinese Patients With Pemphigus Vulgaris and Pemphigus Foliaceus and Literature Review.
Serum Detection of Anti-thyroid Peroxidase and Anti-thyroglobulin Antibodies in Chinese Patients With Pemphigus Vulgaris and Pemphigus Foliaceus and Literature Review.
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中国寻常型天疱疮和落叶型天疱疮患者血清抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体检测及文献复习
DOI：
10.3389/fimmu.2021.653356
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发表时间：
2021
影响因子：
7.3
通讯作者：
Qiao S
中科院分区：
文献类型：
--
作者：
Wang HX;Yang Y;Hu JY;Zhang LM;Cai YF;Guo H;Xiao T;Chen HD;Gao XH;Qiao S
天疱疮是一种罕见但危及生命的自身免疫性皮肤病，其特征是皮肤和/或粘膜起泡。水疱形成的生理过程涉及抗桥粒芯糖蛋白（Dsgs）和桥粒柯林斯（Dscs）的IgG抗体。也有人提出其他自身抗体介导疾病异质性，如抗甲状腺过氧化物酶（抗TPO）和抗甲状腺球蛋白（抗Tg）抗体，它们是自身免疫性甲状腺疾病中免疫系统的罪魁祸首。目的探讨天疱疮患者血清中抗TPO和抗Tg抗体的水平及阳性率。检查天疱疮患者与健康对照相比的抗体阳性和抗TPO和抗Tg抗体水平。通过回顾6项类似研究进行荟萃分析。98例天疱疮患者和65例健康对照者入组研究。我们的荟萃分析显示，阳性抗TPO和抗Tg抗体的增加与天疱疮，特别是寻常型天疱疮（PV）之间存在显著相关性。在我们自己的住院PV患者中也观察到了这种相关性，但在落叶性天疱疮（PF）患者中没有观察到。此外，还比较了PV患者、PF患者或对照组中女性和男性的抗TPO和抗Tg抗体状态，以及天疱疮患者和对照组中女性或男性的抗TPO和抗Tg抗体状态。在T细胞计数分析中，我们发现CD 3 + T细胞计数异常低（< 690 n/µl）仅在甲状腺抗体水平低于20 IU/ml的患者中检测到。天疱疮患者的抗TPO和抗Tg抗体水平和抗体阳性率均高于健康对照组。需要进一步的研究来确定这些抗体在天疱疮中的致病功能，以及确定潜在的共有易感基因。
Pemphigus is a rare but life-threatening autoimmune skin disease characterized by blistering on skin and/or mucous membranes. The physiological process of blister formation involves IgG antibodies against the desmogleins (Dsgs) and desmocollins (Dscs). Additional autoAbs have also been suggested to mediate the disease heterogeneity, such as anti-thyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies, the essential culprits of the immune system in autoimmune thyroid diseases. To investigate the levels and antibody positivity of anti-TPO and anti-Tg antibodies in pemphigus patients. Antibody positivity and levels of anti-TPO and anti-Tg antibodies in pemphigus patients as compared to healthy controls were examined. A meta-analysis was conducted by reviewing six similar studies. 98 Chinese pemphigus patients and 65 healthy controls were enrolled in the study. Our meta-analysis revealed a significant correlation between increased presence of positive anti-TPO and anti-Tg antibodies and pemphigus, particularly for pemphigus vulgaris (PV). Such correlation was also observed in our own hospitalized PV patients, but not in pemphigus foliaceus (PF) patients. In addition, the status of anti-TPO and anti-Tg antibodies were also compared between females and males within PV patients, PF patients or controls, as well as compared for females or males between pemphigus patients and controls. In the analysis of T cell counts, we found abnormal low CD3 + T cell counts (< 690 n/µl) were only detected in patients whose thyroid antibody levels were less than 20 IU/ml. Pemphigus patients showed higher levels and antibody positivity of anti-TPO and anti-Tg antibodies than healthy controls. Further investigations are needed to identify the pathogenic functions of these antibodies in pemphigus, as well as to identify the potential shared susceptibility genes.
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