Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis.
Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis.
复制标题
Beclin 1在卵巢组织中的表达及其对卵巢癌预后的影响
DOI：
10.3390/ijms15045292
复制
发表时间：
2014-03-26
影响因子：
5.6
通讯作者：
Lin B
中科院分区：
文献类型：
--
作者：
Cai M;Hu Z;Liu J;Gao J;Liu C;Liu D;Tan M;Zhang D;Lin B
Beclin 1是一种自噬相关蛋白，参与细胞凋亡和耐药性，以及各种恶性肿瘤。我们研究了Beclin 1蛋白在卵巢上皮组织中的表达及其与卵巢癌预后的关系。采用免疫组化法检测148例卵巢上皮性癌、26例卵巢交界性肿瘤、25例卵巢良性肿瘤和30例正常卵巢组织中Beclin 1蛋白的表达。分析Beclin 1蛋白表达与卵巢癌病理特征的关系。采用考克斯回归模型分析影响卵巢癌预后的危险因素。对93例卵巢癌患者的随访资料绘制生存曲线，分析Beclin 1表达对卵巢癌预后的影响。Beclin 1在卵巢上皮性癌（148例）和交界性肿瘤（26例）中的阳性表达率明显高于卵巢良性肿瘤（25例）和正常卵巢组织（30例）（均P < 0.001）。手术分期和Beclin 1表达是影响卵巢癌预后的独立危险因素（均P < 0.05）。Beclin 1水平高的患者的生存率高于Beclin 1水平低的患者（p = 0.009）。Beclin 1蛋白在卵巢上皮性癌中表达上调，是卵巢癌的预后因子。
Beclin 1 is an autophagy-associated protein involved in apoptosis and drug resistance, as well as various malignancies. We investigated the expression of Beclin 1 protein in ovarian epithelial tissues and correlated it with the prognosis of ovarian cancer. Beclin 1 protein expression was determined using immunohistochemistry in 148 patients with ovarian epithelial cancer, 26 with ovarian borderline tumor, 25 with benign ovarian tumor, and 30 with normal ovarian tissue. The relationships between Beclin 1 protein expression and ovarian cancer pathological characteristics were analyzed. The risk factors for ovarian cancer prognosis were analyzed using Cox’s regression model. A survival curve was plotted from the follow-up data of 93 patients with ovarian cancer to analyze the effects of Beclin 1 expression on the prognosis of ovarian cancer. The positive rates of Beclin 1 were significantly higher in ovarian epithelial cancer (148) and borderline tumor (26) than in benign ovarian tumor (25) or normal ovarian tissue (30) (all p < 0.001). The surgical stage and Beclin 1 expression were both independent risk factors for ovarian cancer prognosis (both p < 0.05). Patients with high Beclin 1 levels showed better survival than those with low Beclin 1 levels (p = 0.009). Beclin 1 protein is upregulated in ovarian epithelial cancer and is a prognostic factor of ovarian cancer.
登录
查看更多内容
影响因子：
56.9
作者：
FUTREAL, PA;LIU, QY;WISEMAN, R
通讯作者：
WISEMAN, R
影响因子：
10.5
作者：
Mathew, Robin;Kongara, Sameera;White, Eileen
通讯作者：
White, Eileen
影响因子：
13.3
作者：
Huang, Jia-Jia;Li, Hao-Ran;Li, Zhi-Ming
通讯作者：
Li, Zhi-Ming
Beclin 1的异常表达与卵巢上皮癌的发生、分化、进展和预后密切相关
影响因子：
--
作者：
Zhao, Yang;Chen, Shuo;Zheng, Hua-chuan
通讯作者：
Zheng, Hua-chuan
Beclin 1 在肝内胆管细胞癌中的预后意义
影响因子：
13.3
作者：
Dong, Li-Wei;Hou, Yu-Jie;Wang, Hong-Yang
通讯作者：
Wang, Hong-Yang