Tolerogenic plasmacytoid DC.
Tolerogenic plasmacytoid DC.
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DOI：
10.1002/eji.201040839
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发表时间：
2010-10
影响因子：
5.4
通讯作者：
Thomson, Angus W.
中科院分区：
文献类型：
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作者：
Matta, Benjamin M.;Castellaneta, Antonino;Thomson, Angus W.
浆细胞样（p）DC是I型IFN产生细胞，已知其促进抗病毒先天性和适应性免疫应答的能力。尽管pDC具有有效的抗病毒功能，但与常规DC（cDC）相比，pDC表现出较差的免疫刺激能力，并且它们与T细胞的相互作用通常有利于Treg的产生。pDC主要分别通过TLR7和TLR9响应于单链（ss）RNA和ss DNA而被激活，但也通过TLR非依赖性机制被激活。非淋巴组织pDC，如存在于气道、肠道和肝脏中的pDC，在调节粘膜免疫中起重要作用，并且对于对吸入或摄入的Ag的耐受性的发展至关重要。在本文中，我们讨论了定义致耐受性pDC的性质以及它们的独特特征如何转化为调节免疫力和促进耐受性发展的能力。我们涵盖了pDC在胸腺内Treg发育和外周耐受维持过程中的重要性，以及它们在移植、自身免疫和癌症中的调节作用。我们强调了最近的研究结果，关于危险和病原体相关的分子模式（DAMP和PAMP，分别）信号在调节pDC功能，以及如何的能力，促进耐受性转化为这些细胞作为治疗靶点，以调节免疫反应的潜在临床应用。
Plasmacytoid (p)DC are type-I IFN-producing cells known for their capacity to promote anti-viral innate and adaptive immune responses. Despite their potent anti-viral function, when compared to conventional DC (cDC), pDC exhibit poor immunostimulatory ability and their interaction with T cells often favors the generation of Treg. pDC are activated primarily in response to single-stranded (ss) RNA and ss DNA through TLR7 and TLR9, respectively, but also through TLR-independent mechanisms. Non-lymphoid tissue pDC, such as those residing in the airways, gut, and liver, play a significant role in regulating mucosal immunity and are critical for the development of tolerance to inhaled or ingested Ags. Herein we discuss properties that define tolerogenic pDC and how their unique characteristics translate into an ability to regulate immunity and promote the development of tolerance. We cover the importance of pDC during intrathymic Treg development and the maintenance of peripheral tolerance, as well as their regulatory role in transplantation, autoimmunity, and cancer. We highlight recent findings regarding danger- and pathogen-associated molecular pattern (DAMP and PAMP, respectively) signaling in the regulation of pDC function, and how the ability of pDC to promote tolerance translates into the potential clinical applications of these cells as therapeutic targets to regulate immune reactivity.
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影响因子：
6.1
作者：
Bratke, K.;Nielsen, J.;Virchow, J. C.
通讯作者：
Virchow, J. C.
DOI：
10.4049/jimmunol.0900582
发表时间：
2009-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Castellaneta A;Sumpter TL;Chen L;Tokita D;Thomson AW
通讯作者：
Thomson AW
影响因子：
32.4
作者：
Goubier, Anne;Dubois, Bertrand;Gheit, Hanane;Joubert, Grgoire;Villard-Truc, Florence;Asselin-Paturel, Carine;Trinchieri, Giorgio;Kaiserlian, Dominique
通讯作者：
Kaiserlian, Dominique
影响因子：
4.4
作者：
Jahnsen, FL;Lund-Johansen, F;Brandtzaeg, P
通讯作者：
Brandtzaeg, P
影响因子：
30.5
作者：
通讯作者：
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