Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study.
Combined therapeutic effect of probucol and cilostazol on endothelial function in patients with silent cerebral lacunar infarcts and hypercholesterolemia: a preliminary study.
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DOI：
10.1159/000355825
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ishihara M
中科院分区：
文献类型：
--
作者：
Takase B;Nagata M;Hattori H;Tanaka Y;Ishihara M
本研究评价了普罗布考和西洛他唑联合治疗对无症状腔隙性脑梗死（SLCI）和轻度高胆固醇血症患者内皮功能的疗效。在普罗布考联合治疗4周前后测定血流介导的血管舒张（FMD）和硝酸甘油诱导的血管舒张（NMD）（500 mg/天）和西洛他唑（200 mg/天），34例平均年龄为72 ± 7岁的患者（范围57-80岁），伴有SLCI、轻度高胆固醇血症（低密度脂蛋白胆固醇>100 mg/dl）和内皮功能受损（FMD <6%）。患者被随机分配到以下两个治疗组之一：（1）阿司匹林（100 mg/天）与行为的修改，如饮食和/或运动疗法（A组或对照组，n = 17），和（2）普罗布考和西洛他唑治疗（PC组，n = 17），也与行为的修改。尽管两个治疗组之间的基线FMD没有差异（2.7 ± 1.5 vs. 2.6 ± 1.5%，n.s.），PC组治疗后FMD明显改善（从2.7 ± 1.5%改善至3.5 ± 1.7%，p < 0.05），而A组治疗后FMD无明显改善（从2.6 ± 1.5%改善至2.9 ± 1.4%，n. s.）。两组基线和治疗后NMD无差异。在PC组中，治疗对血脂谱的影响更为深远。普罗布考和西洛他唑联合治疗可亚急性改善伴有轻度高胆固醇血症的SLCI患者的FMD/内皮功能。这种联合治疗有可能通过改善内皮功能和血脂来降低心血管事件的风险。
This study evaluated the efficacy of combined therapy with probucol and cilostazol on endothelial function in silent lacunar cerebral infarcts (SLCI) and mild hypercholesterolemia. Flow-mediated vasodilatation (FMD) and nitroglycerin-induced vasodilatation (NMD) were measured before and after 4 weeks of combined therapy with probucol (500 mg/day) and cilostazol (200 mg/day) in 34 patients with a mean age of 72 ± 7 years (range 57-80 years) with SLCI, mild hypercholesterolemia (low-density lipoprotein cholesterol >100 mg/dl) and impaired endothelial function (FMD <6%). Patients were randomly allocated to one of the following two treatment groups: (1) aspirin (100 mg/day) with behavioral modifications, such as diet and/or exercise therapy (A group or control group, n = 17), and (2) probucol and cilostazol treatment (PC group, n = 17), also with behavioral modifications. Although the baseline FMD was not different between the two treatment arms (2.7 ± 1.5 vs. 2.6 ± 1.5%, n.s.), the posttreatment FMD was significantly improved in the PC group (from 2.7 ± 1.5 to 3.5 ± 1.7%, p < 0.05) but not in the A group (from 2.6 ± 1.5 to 2.9 ± 1.4%, n.s.). No differences were observed between baseline and posttreatment NMD in either group. The effects of treatments on lipid profiles were more profound in the PC group. Combined treatment with probucol and cilostazol resulted in subacute improvement in FMD/endothelial function in patients with SLCI with mild hypercholesterolemia. This combination therapy has the potential to reduce the risk of cardiovascular events via improvements in endothelial function and lipid profiles.
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影响因子：
2.9
作者：
Grau-Olivares, Marta;Bartres-Faz, David;Junque, Carme
通讯作者：
Junque, Carme
影响因子：
5.3
作者：
Okutsu, Reiko;Yoshikawa, Tomohiro;Yabuuchi, Youichi
通讯作者：
Yabuuchi, Youichi
在缺血和再灌注条件下，西洛替唑对孤立的兔股动脉的保护作用：一氧化氮途径的作用。
DOI：
10.6061/clinics/2012(02)13
发表时间：
2012
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Santos MR;Celotto AC;Capellini VK;Evora PR;Piccinato CE;Joviliano EE
通讯作者：
Joviliano EE
影响因子：
2.8
作者：
Takase, B;Uehata, A;Kurita, A
通讯作者：
Kurita, A
影响因子：
9.9
作者：
Bernick, C;Kuller, L;Price, T
通讯作者：
Price, T