Biological and psychosocial factors associated with the persistence of pruritus symptoms: protocol for a prospective, exploratory observational study in Germany (individual project of the Interdisciplinary SOMACROSS Research Unit [RU 5211]).
Biological and psychosocial factors associated with the persistence of pruritus symptoms: protocol for a prospective, exploratory observational study in Germany (individual project of the Interdisciplinary SOMACROSS Research Unit [RU 5211]).
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DOI：
10.1136/bmjopen-2022-060811
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发表时间：
2022-07-07
期刊：
影响因子：
2.9
通讯作者：
Schneider, Stefan W.
中科院分区：
文献类型：
--
作者：
Schneider, Gudrun;Staender, Sonja;Kahnert, Stefan;Pereira, Manuel Pedro;Mess, Christian;Huck, Volker;Agelopoulos, Konstantin;Frank, Gina;Schneider, Stefan W.
慢性瘙痒症（CP）是皮肤病、神经系统疾病、全身性疾病和心身疾病的症状。CP在一般人群中的患病率约为20%，因此是社会的重大负担，但从急性瘙痒症到CP的转变尚不清楚。它可能涉及生物和心理社会因素之间的相互作用，以及与SOMACROSS研究单位（RU）其他项目中涉及的其他持续性躯体症状共享的机制。在这里，我们的目的是确定心理和生物因素及其相互作用，这可能与持久性CP与免疫/炎症的起源，即特应性皮炎和瘙痒症的非炎症皮肤。我们预计，与症状持续相关的心理社会因素，如疲劳和疼痛，也可能与CP有关。在这项位于德国的前瞻性、探索性观察性研究中，将招募3个队列（各40例异位性皮炎和慢性异位性皮炎急性加重患者）和40例皮肤未受影响的CP患者，进行全面的转化研究，包括RU SOMACROSS的特异性和共享的社会心理评估。瘙痒特异性指标将包括问卷调查、定量感觉测试、皮肤神经纤维形态学、皮肤屏障形态学、表皮代谢和过敏原血液水平。在1年内，将在3个时间点对患者和80名年龄匹配和性别匹配的健康对照进行检查，允许根据现有指南对接受治疗的患者的预测结局因素进行横断面比较和纵向调查。本研究已获得德国汉堡（2020-10200-BO-ff）和明斯特（2020-676 f-S）伦理委员会的批准。所有参与者均需提供书面知情同意书。研究结果将通过同行评审的出版物、科学会议以及相关利益攸关方、患者和普通公众的参与进行传播。DRKS 00026646。
Chronic pruritus (CP) is a symptom of dermatologic, neurologic, systemic and psychosomatic diseases. CP has a prevalence of ~20% in the general population and is therefore a significant burden on society, but the transition from acute pruritus to CP is not well understood. It probably involves interactions between biological and psychosocial factors and pruritus-specific risk factors as well as mechanisms shared with other persistent somatic symptoms addressed in other projects of the SOMACROSS Research Unit (RU). Here we aim to identify psychosocial and biological factors and their interactions which might be associated with the persistence of CP with and without immunologic/inflammatory origin, that is, atopic dermatitis and pruritus on non-inflamed skin. We expect that psychosocial factors relevant to the persistence of symptoms such as fatigue and pain may also show associations to CP. In this prospective, exploratory observational study situated in Germany, three cohorts of 40 patients each with acute exacerbation of atopic dermatitis and chronic atopic dermatitis and 40 CP patients with unaffected skin will be recruited for a comprehensive translational investigation including pruritus-specific and the shared psychosocial assessments of the RU SOMACROSS. Pruritus-specific measures will include questionnaires, quantitative sensory testing, cutaneous nerve fibre morphology, skin barrier morphology, epidermal metabolism and pruritogen blood levels. Within 1 year, patients and 80 age-matched and sex-matched healthy controls will be examined at three time points, allowing cross-sectional comparison and a longitudinal investigation of predictive outcome factors in patients under treatment according to existing guidelines. The study has been approved by the ethics committees of Hamburg (2020-10200-BO-ff) and Münster (2020-676 f-S), Germany. All participants are required to provide written informed consent. Findings will be disseminated through peer-reviewed publications, scientific conferences and involvement of relevant stakeholders, patients and the lay public. DRKS00026646.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
3.3
作者：
Rief, Winfried;Burton, Chris;van der Feltz-Cornelis, Christina
通讯作者：
van der Feltz-Cornelis, Christina
影响因子：
22.8
作者：
Henningsen, Peter;Zipfel, Stephan;Creed, Francis
通讯作者：
Creed, Francis
DOI：
10.1126/science.aar5703
发表时间：
2018-05-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Feng J;Luo J;Yang P;Du J;Kim BS;Hu H
通讯作者：
Hu H
影响因子：
6.5
作者：
Pogatzki-Zahn, Esther M.;Pereira, Manuel P.;Staender, Sonja
通讯作者：
Staender, Sonja