Extranodal connective tissue invasion and the expression of desmosomal glycoprotein 1 in squamous cell carcinoma of the oesophagus.
Extranodal connective tissue invasion and the expression of desmosomal glycoprotein 1 in squamous cell carcinoma of the oesophagus.
复制标题
食管鳞状细胞癌结外结缔组织侵袭和桥粒糖蛋白1的表达。
作者：
S. Natsugoe;J. Mueller;F. Kijima;K. Aridome;Mitsuo Shimada;K. Shirao;C. Kusano;M. Baba;H. Yoshinaka;T. Fukumoto;T. Aikou
我们研究了39例食管癌结外结缔组织受累（ECTI）。采用单克隆抗体32-2B检测桥粒糖蛋白1 (DG1)，对原发肿瘤和ECTI进行免疫组织化学检测。结缔组织癌沉积物被确定为小淋巴结内的细胞，淋巴或静脉血管浸润或转移性淋巴结囊外的广泛浸润。39例患者中有20例（51.3%）在至少一个部位出现上述组织学表现。肿瘤DG1免疫染色强度分为DG1（++）、DG1（+）和DG1（-）。DG1（+）或DG1（-）原发肿瘤发生淋巴结转移和ECTI的频率高于DG1（++）肿瘤（P<0.05）。17例行ECTI DG1免疫组化的患者中，DG1(++) 3例，DG1(+) 5例，DG1(-) 9例。ECTI的DG1表达水平与原发肿瘤相同或低于原发肿瘤。这些结果表明，DG1表达的减少或缺失可能促进ECTI和淋巴结转移。人们应该意识到食管癌中发生ECTI的可能性。在未来，根据个别癌细胞的表型，包括DG1的表达，辅助治疗可能是一些食管癌的可取之选。
We investigated extranodal connective tissue involvement (ECTI) in 39 patients with oesophageal carcinoma. Both the primary tumour and ECTI were immunohistochemically examined using the monoclonal antibody 32-2B for desmosomal glycoprotein 1 (DG1). Connective tissue carcinoma deposits were identified as cells within small lymph nodes, as lymphatic or venous vessel invasion or as widespread invasion beyond the capsule of metastatic lymph nodes. These histological findings were present in at least one area in 20 of 39 patients (51.3%). DG1 immunostaining intensity by tumour was graded as DG1 (++), DG1 (+) or DG1 (-). DG1 (+) or DG1 (-) primary tumours demonstrated lymph node metastases and ECTI more frequently than DG1(++) tumours (P<0.05). Among 17 patients in whom DG1 immunohistochemistry was performed on ECTI, there were three DG1(++), five DG1(+) and nine DG1(-) patients. The DG1 expression of ECTI was equal to or less intense than the primary tumour. These results indicate that reduction or loss of DG1 expression may promote ECTI and lymph node metastases. One should be aware of the potential for ECTI in oesophageal carcinomas. In the future, adjuvant therapy may be advisable for some oesophageal carcinomas based on the phenotype of individual cancer cells, including expression of DG1.
桥粒芯糖蛋白与细胞粘附分子钙粘蛋白家族具有广泛的同源性。
DOI：
10.1016/s0006-291x(05)80917-9
发表时间：
1990
影响因子：
3.1
作者：
Goodwin,L;Hill,JE;Raynor,K;Raszi,L;Manabe,M;Cowin,P
通讯作者：
Cowin,P
影响因子：
45.3
作者：
KELSEN, DP;MINSKY, B;HILARIS, B
通讯作者：
HILARIS, B