Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.
Hepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.
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肝因子孕区蛋白通过激活棕色脂肪组织来控制饮食诱导的生热作用
DOI：
10.1002/advs.202101991
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Jin W
中科院分区：
文献类型：
--
作者：
Lin J;Jiang X;Dong M;Liu X;Shen Q;Huang Y;Zhang H;Ye R;Zhou H;Yan C;Yuan S;Wu X;Chen L;Wang Y;He M;Tao Y;Zhang Z;Jin W
间歇性禁食（IF）作为减肥的饮食干预，主要通过增加能量消耗来发挥作用。然而，器官间系统是否在IF中发挥关键作用仍不清楚。在这里，一种新的肝细胞因子，妊娠区蛋白（PZP）被确定，它具有显着的诱导在再喂养阶段的IF。此外，小鼠功能丧失研究和蛋白质治疗实验表明，PZP通过激活棕色脂肪组织（BAT）促进饮食诱导的产热作用。从机制上讲，循环PZP可以与细胞表面78 kDa葡萄糖调节蛋白（GRP 78）结合，通过BAT中的p38 MAPK-ATF 2信号通路促进解偶联蛋白1（UCP 1）表达。这些研究阐明了IF通过内分泌系统促进BAT产热的系统调节，并为治疗肥胖和相关疾病提供了新的潜在靶点。本文报道了一种新的肝细胞因子-妊娠带蛋白（PZP），它在再喂养诱导中具有重要作用。小鼠功能丧失研究和蛋白质治疗实验表明，PZP通过激活棕色脂肪组织（BAT）中的p38 MAPK-ATF 2-UCP 1信号通路促进饮食诱导的产热。这些研究为治疗肥胖和相关疾病提供了新的潜在靶点。
Intermittent fasting (IF), as a dietary intervention for weight loss, takes effects primarily through increasing energy expenditure. However, whether inter‐organ systems play a key role in IF remains unclear. Here, a novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss of function studies and protein therapeutic experiment in mice revealed that PZP promotes diet‐induced thermogenesis through activating brown adipose tissue (BAT). Mechanistically, circulating PZP can bind to cell surface glucose‐regulated protein of 78 kDa (GRP78) to promote uncoupling protein 1 (UCP1) expression via a p38 MAPK‐ATF2 signaling pathway in BAT. These studies illuminate a systemic regulation in which the IF promotes BAT thermogenesis through the endocrinal system and provide a novel potential target for treating obesity and related disorders. This paper reports a novel hepatokine, pregnancy zone protein (PZP), which is significant induction by refeeding. Loss of function studies and protein therapeutic experiment in mice reveal that PZP promotes diet‐induced thermogenesis through activating brown adipose tissue (BAT) via p38 MAPK‐ATF2‐UCP1 signaling pathway in BAT. These studies provide a novel potential target for treating obesity and related disorders.
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