Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.
Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients.
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DOI：
10.1007/s00428-021-03033-5
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Murakami K
中科院分区：
文献类型：
--
作者：
Wada Y;Nakajima S;Kushima R;Takemura S;Mori N;Hasegawa H;Nakayama T;Mukaisho KI;Yoshida A;Umano S;Yamamoto K;Sugihara H;Murakami K
胃体幽门腺样化生有两种类型：幽门型和假幽门型。在H&E染色中，它们显示出与原始幽门腺相同的形态。胃蛋白酶原（PG）I免疫组化染色假幽门化生阳性，而幽门化生阴性。最近，痉挛性多肽表达性化生（SPEM）主要在动物实验中被提出用于幽门腺样化生。SPEM表达三叶因子家族2（TFF 2），通常被认为是假幽门化生的同义词。我们回顾了连续22例日本自身免疫性胃炎（AIG）患者，根据更新的悉尼系统，通过计数取自中体大弯活检标本的所有幽门腺样腺体，研究TFF 2在幽门和假幽门化生中的表达。22例均见幽门化生，15例为假幽门化生。1567个幽门腺样腺体中，幽门化生腺体1381个（88.1%），假幽门化生腺体186个（11.9%）。20例幽门腺或假幽门腺化生中有TFF 2表达。TFF 2在1381例幽门化生腺体中表达409例（26.9%），在186例假幽门化生腺体中表达27例（14.5%），两者比较有显著性差异（P<0.01）。总之，SPEM并不总是与人AIG中的假幽门化生相同，并且AIG中的大多数化生不是假幽门化生而是幽门化生。在线版本包含补充材料，可通过10.1007/s 00428 -021-03033-5获得。
There are two types of pyloric gland-like metaplasia in the corpus of stomach: pyloric and pseudopyloric metaplasias. They show the same morphology as the original pyloric glands in H&E staining. Pseudopyloric metaplasia is positive for pepsinogen (PG) I immunohistochemically, whereas pyloric metaplasia is negative. Recently, spasmolytic polypeptide-expressing metaplasia (SPEM) is proposed for pyloric gland-like metaplasia mainly in animal experiments. SPEM expresses trefoil factor family 2 (TFF2) and is often considered synonymous with pseudopyloric metaplasia. We reviewed consecutive 22 Japanese patients with autoimmune gastritis (AIG) to investigate TFF2 expression in pyloric and pseudopyloric metaplasias by counting all pyloric gland-like glands in biopsy specimens taken from greater curvature of the middle corpus according to the Updated Sydney System. Pyloric metaplasia was seen in all the 22 cases, and pseudopyloric metaplasia was found in 15 cases. Of 1567 pyloric gland-like glands in all the cases, 1381 (88.1%) glands were pyloric metaplasia glands, and the remaining 186 (11.9%) glands were pseudopyloric metaplasia glands. TFF2 expression was observed in pyloric or pseudopyloric metaplasia glands in 20 cases. TFF2 expression was recognized in 409 of 1381 (26.9%) pyloric metaplasia glands and 27 of 186 (14.5%) pseudopyloric metaplasia glands (P<0.01, chi-square test). In conclusion, SPEM was not always the same as pseudopyloric metaplasia in human AIG, and the majority of metaplasia in AIG was not pseudopyloric but pyloric metaplasia. The online version contains supplementary material available at 10.1007/s00428-021-03033-5.
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影响因子：
2.5
作者：
Graham DY;Zou WY
通讯作者：
Zou WY
影响因子：
3.5
作者：
La Rosa, Stefano;Franzi, Francesca;Capella, Carlo
通讯作者：
Capella, Carlo
DOI：
10.1007/bf02892834
发表时间：
1982-01-01
期刊：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY
影响因子：
--
作者：
HATTORI, T;HELPAP, B;GEDIGK, P
通讯作者：
GEDIGK, P
影响因子：
6
作者：
Lennerz, Jochen K. M.;Kim, Seok-Hyung;Mills, Jason C.
通讯作者：
Mills, Jason C.
影响因子：
5.6
作者：
KRISHNAMURTHY, S;DAYAL, Y
通讯作者：
DAYAL, Y