Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.
Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.
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DOI：
10.1016/j.neubiorev.2017.05.022
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发表时间：
2018-03
影响因子：
8.2
通讯作者：
Kline AE
中科院分区：
文献类型：
--
作者：
de la Tremblaye PB;O'Neil DA;LaPorte MJ;Cheng JP;Beitchman JA;Thomas TC;Bondi CO;Kline AE
本综述的目的是讨论在2016年国际行为神经科学学会年会上提出的题为“表征实验性CNS损伤治疗策略和挑战的当前进展”的研讨会上提出的研究。在此，我们讨论弥漫性和局灶性创伤性脑损伤（TBI）和随之而来的慢性行为缺陷以及潜在的康复方法。我们还讨论了TBI后应激对执行功能的影响以及内分泌系统的反应和调节反馈机制。中枢神经系统损伤后的内源性大麻素的作用进行了讨论。最后，我们总结了抗精神病药物和抗癫痫药物的讨论，这是提供控制TBI诱导的躁动和癫痫发作，分别。该综述主要由已发表的数据组成。
The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury” which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.
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DOI：
10.1111/j.1749-6632.2003.tb07508.x
发表时间：
2003-01-01
期刊：
NEUROPROTECTIVE AGENTS
影响因子：
--
作者：
Alves, OL;Doyle, AJ;Bullock, R
通讯作者：
Bullock, R
影响因子：
2.2
作者：
Ängehagen, M;Ben-Menachem, E;Hansson, E
通讯作者：
Hansson, E
影响因子：
4.2
作者：
Belayev, L;Alonso, OF;Busto, R
通讯作者：
Busto, R
影响因子：
4.7
作者：
Aso, Ester;Ozaita, Andres;Valverde, Olga
通讯作者：
Valverde, Olga
影响因子：
9.3
作者：
Berardi, Andrea;Schelling, Gustav;Campolongo, Patrizia
通讯作者：
Campolongo, Patrizia