Incidence of otitis media in a contemporary Danish National Birth Cohort.
Incidence of otitis media in a contemporary Danish National Birth Cohort.
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DOI：
10.1371/journal.pone.0111732
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Homøe P
中科院分区：
文献类型：
--
作者：
Todberg T;Koch A;Andersson M;Olsen SF;Lous J;Homøe P
近年来，丹麦的福利有所增加，这可能会减少中耳炎（OM）的发病率。我们研究了1996-2003年出生的0-7岁儿童的全国队列（丹麦国家出生队列，DNBC）的年龄特异性OM发病率。唯一的选择是能够理解和说丹麦语。在6个月、18个月和7岁时通过3次母亲访谈收集OM和通气管（VT）的信息，并在此基础上计算OM的年龄特异性和累积发病率。由于总人口中回答不同访谈的人数不同，因此计算采用不同的分母。DNBC中的信息与两个包含VT插入信息的基于种群的登记处进行了验证。7年累计发病率为60.6%（31982 /52,755）。对于患有OM的儿童，16.2%（7143/44194）在0-6个月之间首次发作OM， 44.3%（19579/44194）在7 - 18个月之间，39.5%（17472/44194）在19个月至7岁之间。39.5%（12620/31982）和64.0%（2482/3881）在0-6个月间首次发作OM的患者报告在7岁前发生4次或以上OM；上涨48.2%(4998/10378)，首个月为7-18个月；在19个月至7年之间首次亮相时，增长28.7%（4996/17344）。这些数字与丹麦早先的数字基本没有变化。在7年的随访中，有26.1%的患者报告了至少一次VT插入。假设丹麦国家患者登记处的记录是金标准，产妇在DNBC中对VT插入的自我报告具有高敏感性（96.4%），特异性（98.2%），阳性预测值（94.8%）和阴性预测值（98.8%）。尽管已知的OM危险因素有所减少，但丹麦近三分之二的学龄前儿童受到OM的影响。
In recent years welfare in Denmark has increased which might be expected to reduce otitis media (OM) incidence. We examined the age-specific incidence of OM in a nation-wide cohort of children aged 0–7 years born in 1996–2003 (Danish National Birth Cohort, DNBC). Only selection was ability to understand and speak Danish. Information of OM and ventilation tubes (VT) was collected through three maternal interviews at 6-month, 18-month and 7-years of age and based on this age-specific and cumulative incidence of OM was calculated. As different numbers of the total population answered the different interviews, the calculations are done with different denominators. The information in DNBC was validated against two population based registries containing information of VT insertions. Cumulative incidence of OM at 7 years was 60.6% (31,982/52,755). For children with OM, 16.2% (7143/44194) had their first OM episodes between 0–6 months of age, 44.3% (19579/44194) between 7–18 months, and 39.5% (17472/44194) between 19 months and 7 years. Four or more OM episodes before 7 years were reported by 39.5% (12620/31982) and by 64.0% (2482/3881) of those who had their OM debut between 0–6 months; by 48.2% (4998/10378) with debut between 7–18 months; and by 28.7% (4996/17344) with debut between 19 months and 7 years. These figures are essentially unchanged from earlier figures from Denmark. VT insertion at least once was reported by 26,1% in the 7-year interview. Assuming recordings in the Danish National Patient Registry to be gold standard, maternal self-reportings in DNBC of insertion of VT showed high sensitivity (96.4%), specificity (98.2%), and positive (94.8%) and negative predictive values (98.8%). OM affects nearly 2/3 of preschool children in Denmark despite reduction in known OM risk factors.
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影响因子：
3.6
作者：
Jensen, Ramon Gordon;Koch, Anders;Homoe, Preben
通讯作者：
Homoe, Preben
影响因子：
3.4
作者：
Rosenfeld, Richard M.;Schwartz, Seth R.;Schellhase, Kenneth G.
通讯作者：
Schellhase, Kenneth G.
影响因子：
13.6
作者：
Labout, Joost A. M.;Duijts, Liesbeth;Lebon, Ankie;de Groot, Ronald;Hofman, Albert;Jaddoe, Vincent V. W.;Verbrugh, Henri A.;Hermans, Peter W. M.;Moll, Henriette A.
通讯作者：
Moll, Henriette A.
影响因子：
5.4
作者：
Nohr, EA;Frydenberg, M;Olsen, J
通讯作者：
Olsen, J
DOI：
10.1016/j.ijporl.2007.03.010
发表时间：
2007-07-01
影响因子：
1.5
作者：
Karevold, Gunnhild;Haapkyla, Johanna;Kvaerner, Kari Jorunn
通讯作者：
Kvaerner, Kari Jorunn