Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study.
Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: the Generation R study.
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DOI：
10.1007/s10654-010-9500-2
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发表时间：
2011-01
影响因子：
13.6
通讯作者：
Moll, Henriette A.
中科院分区：
文献类型：
--
作者：
Labout, Joost A. M.;Duijts, Liesbeth;Lebon, Ankie;de Groot, Ronald;Hofman, Albert;Jaddoe, Vincent V. W.;Verbrugh, Henri A.;Hermans, Peter W. M.;Moll, Henriette A.
急性中耳炎是最常见的诊断儿童访问医生的办公室。中耳炎的危险因素已被广泛研究。然而，细菌携带和中耳炎的发展之间的相关性并不完全清楚。我们的目的是在一个以人群为基础的前瞻性队列中研究出生后第二年中耳炎的危险因素，特别强调肺炎链球菌、流感嗜血杆菌和卡他莫拉菌定植的作用。该研究被嵌入到R世代研究中。通过助产士、医院登记和邮寄问卷调查获得整个队列（n = 7，295）的风险因素和医生诊断的中耳炎数据。在重点队列（n = 1，079）中，在1.5、6和14个月龄时获得鼻咽拭子。在这些儿童中，2，515名（47.2%）在其生命的第二年至少患有一次中耳炎。出生后6个月和6 - 12个月随访期间中耳炎的发生与出生后第二年中耳炎的风险相关（aOR，1.83，95% CI 1.24-2.71和aOR 2.72，95% CI 2.18-3.38）。有兄弟姐妹与出生后第二年患中耳炎的风险增加相关（aOR 1.42，95%CI 1.13-1.79）。未发现第一年细菌携带与第二年中耳炎之间存在关联。在我们的研究中，出生后第一年的中耳炎是出生后第二年中耳炎的独立危险因素。令人惊讶的是，生命第一年的细菌携带并没有增加这种风险。此外，在出生后第一年的细菌携带和第二年的耳炎之间没有观察到任何联系。
Acute otitis media is the most frequent diagnosis in children visiting physicians’ offices. Risk factors for otitis media have been widely studied. Yet, the correlation between bacterial carriage and the development of otitis media is not entirely clear. Our aim was to study in a population-based prospective cohort the risk factors for otitis media in the second year of life with special emphasis on the role of colonization with Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. The study was embedded in the Generation R Study. Data on risk factors and doctor-diagnosed otitis media were obtained by midwives, hospital registries and postal questionnaires in the whole cohort (n = 7,295). Nasopharyngeal swabs were obtained at the age of 1.5, 6 and 14 months in the focus cohort (n = 1,079). Of these children, 2,515 (47.2%) suffered at least one period of otitis media in their second year of life. The occurrence of otitis media during the follow-up period in the first 6 months of life and between 6 and 12 months of age was associated with the risk of otitis media in the second year of life (aOR, 1.83 95% CI 1.24–2.71 and aOR 2.72, 95% CI 2.18–3.38, respectively). Having siblings was associated with an increased risk for otitis media in the second year of life (aOR 1.42, 95% CI 1.13–1.79). No associations were found between bacterial carriage in the first year of life and otitis media in the second year of life. In our study, otitis media in the first year of life is an independent risk factor for otitis media in the second year of life. Surprisingly, bacterial carriage in the first year of life did not add to this risk. Moreover, no association was observed between bacterial carriage in the first year of life and otitis in the second year of life.
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影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Hofman, Albert
通讯作者：
Hofman, Albert
影响因子：
1.4
作者：
PRELLNER, K;CHRISTENSEN, P;ROSEN, C
通讯作者：
ROSEN, C
影响因子：
6.4
作者：
FADEN, H;HARABUCHI, Y;HONG, JJ
通讯作者：
HONG, JJ
影响因子：
6.4
作者：
HARABUCHI, Y;FADEN, H;KRYSTOFIK, D
通讯作者：
KRYSTOFIK, D
影响因子：
6.4
作者：
TEELE, DW;KLEIN, JO;ROSNER, B
通讯作者：
ROSNER, B