Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.
Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.
复制标题
DOI：
10.1016/j.peptides.2009.03.006
复制
发表时间：
2009-06
期刊：
影响因子：
3
通讯作者：
Mulholland MW
中科院分区：
文献类型：
--
作者：
Chai B;Li JY;Zhang W;Wang H;Mulholland MW
The melanocortin system is crucial to regulation of energy homeostasis. The melanocortin receptor type 4 (MC4R) modulates insulin signaling via effects on c-Jun N-terminal kinase (JNK). The melanocortin agonist NDP-MSH dose-dependently inhibited JNK activity in HEK293 cells stably expressing the human MC4R; effects were reversed by melanocortin receptor antagonist. NDP-MSH time- and dose-dependently inhibited IRS-1ser307 phosphorylation, effects also reversed by a specific melanocortin receptor antagonist. NDP-MSH augmented insulin-stimulated AKT phosphorylation in vitro. The melanocortin agonist melanotan II increased insulin-stimulated AKT phosphorylation in the rat hypothalamus in vivo. NDP-MSH increased insulin-stimulated glucose uptake in hypothalamic GT1-1 cells. The current study shows that the melanocortinergic system interacts with insulin signaling via novel effects on JNK activity.
登录
查看更多内容
影响因子：
3.5
作者：
Banno, Ryoichi;Arima, Hiroshi;Oiso, Yutaka
通讯作者：
Oiso, Yutaka
影响因子：
64.8
作者：
Fan, W;Boston, BA;Cone, RD
通讯作者：
Cone, RD
影响因子：
3.3
作者：
Murphy, B;Nunes, CN;Mellin, TN
通讯作者：
Mellin, TN
影响因子：
2.9
作者：
Daniels, D;Patten, CS;Fluharty, SJ
通讯作者：
Fluharty, SJ
影响因子：
7.7
作者：
Hotamisligil, GS
通讯作者：
Hotamisligil, GS