Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study.
Genitourinary disease risks among ovarian cancer survivors in a population-based cohort study.
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DOI：
10.1016/j.ygyno.2020.02.028
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发表时间：
2020-05
影响因子：
4.7
通讯作者：
Hashibe M
中科院分区：
文献类型：
--
作者：
Chang CP;Chen Y;Blackburn B;Abdelaziz S;Rowe K;Snyder J;Dodson M;Deshmukh V;Newman M;Stanford JB;Porucznik CA;Ose J;Fraser A;Smith K;Doherty J;Gaffney D;Hashibe M
虽然卵巢癌治疗期间的泌尿生殖系统并发症众所周知，但长期不良后果尚未得到很好的描述。卵巢癌的幸存者人数一直在增加。本研究的目的是在一个以人群为基础的队列中调查长期不良泌尿生殖结局。我们从犹他州癌症登记处确定了1996年至2012年期间诊断的1，270名卵巢癌幸存者的队列，并从犹他州人口数据库中匹配了5，286名无癌症女性的出生年份和状态。泌尿生殖系统疾病的诊断是通过ICD-9编码从电子病历和全州医疗保健设施数据中确定的。采用考克斯比例风险模型估计卵巢癌诊断后1 - 5年和5年以上泌尿生殖系统结局的风险比（HR）。与一般人群队列相比，卵巢癌幸存者在癌症诊断后1年至<5年期间发生泌尿系统疾病（HR：2.53，95% CI：2.12-3.01）和生殖器官疾病（HR：1.88，95% CI：1.57-2.27）的风险增加。观察到急性肾衰竭、慢性肾脏疾病、肾结石、肾积水、盆腔腹膜粘连和盆腔器官炎症的风险增加。在癌症诊断后5年以上观察到这些疾病中的几种疾病的风险增加。卵巢癌幸存者经历各种泌尿生殖系统疾病的风险增加，与一般人群中的女性相比，长期。了解卵巢癌幸存者的多发病轨迹对于改善癌症治疗完成后的临床护理非常重要。
While genitourinary complications during treatment for ovarian cancer are well known, long-term adverse outcomes have not been well characterized. The number of ovarian cancer survivors has been increasing. The aim of this study was to investigate long-term adverse genitourinary outcomes in a population-based cohort. We identified a cohort of 1,270 ovarian cancer survivors diagnosed between 1996–2012 from the Utah Cancer Registry, and 5,286 cancer-free women were matched on birth year and state from the Utah Population Database. Genitourinary disease diagnoses were identified through ICD-9 codes from electronic medical records and statewide healthcare facilities data. Cox proportional hazards models were used to estimate hazard ratios (HR) for genitourinary outcomes at 1 to <5 years and 5+ years after ovarian cancer diagnosis. Ovarian cancer survivors had increased risks for urinary system disorders (HR: 2.53, 95% CI: 2.12–3.01) and genital organ disorders (HR: 1.88, 95% CI: 1.57–2.27) between 1 and <5 years after cancer diagnosis compared to the general population cohort. Increased risks were observed for acute renal failure, chronic kidney disease, calculus of kidney, hydronephrosis, pelvic peritoneal adhesions, and pelvic organ inflammatory conditions. Increased risks of several of these diseases were observed 5+ years after cancer diagnosis. Ovarian cancer survivors experience increased risks of various genitourinary diseases compared to women in the general population in the long-term. Understanding the multimorbidity trajectory among ovarian cancer survivors is important to improve clinical care after cancer treatment is completed.
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影响因子：
3.8
作者：
Schlumbrecht M;Sun C;Huang M;Milbourne A;Bodurka D
通讯作者：
Bodurka D
影响因子：
4.7
作者：
Soisson, Sean;Ganz, Patricia A.;Hashibe, Mia
通讯作者：
Hashibe, Mia
影响因子：
4.7
作者：
Grover, Surbhi;Hill-Kayser, Christine E.;Metz, James M.
通讯作者：
Metz, James M.
DOI：
10.1097/igc.0000000000000950
发表时间：
2017-05-01
影响因子：
4.8
作者：
Kanninen, Tomi T.;Nasioudis, Dimitrios;Witkin, Steven S.
通讯作者：
Witkin, Steven S.
影响因子：
4.7
作者：
Chia, Victoria M.;O'Malley, Cynthia D.;Griffiths, Robert I.
通讯作者：
Griffiths, Robert I.