Elevated Adipose Triglyceride Lipase in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension
Elevated Adipose Triglyceride Lipase in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension
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新诊断的 2 型糖尿病伴高血压患者脂肪甘油三酯脂肪酶升高
DOI：
10.1097/maj.0b013e318218482f
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发表时间：
2011-12
影响因子：
3.1
通讯作者：
Li, Ling
中科院分区：
文献类型：
--
作者：
Xu, Shengnan;Yang, Gangyi;Yang, Mengliu;Li, Shengbing;Liu, Hua;Li, Ling
简介：脂肪甘油三酯脂肪酶（ATGL）是最近发现的负责脂肪脂解的三酰甘油脂肪酶。其在人类中的病理生理作用尚不清楚。材料与方法：在本研究中，作者研究了2型糖尿病（T2DM）患者、T2DM合并高血压患者和对照组血浆ATGL水平。他们还评估了血浆ATGL与身体成分和代谢参数之间的关系。结果与结论：T2DM合并高血压患者血浆ATGL水平明显高于T2DM患者（78.3±23.4 vs 65.1±22.8,P < 0.01）。血浆ATGL水平无性别差异。此外，在汇总数据的简单回归分析中，他们发现血浆ATGL水平与总胆固醇（r = 0.17, P < 0.05）和高密度脂蛋白C （r = 0.16, P < 0.05）呈正相关，而在多元逐步回归分析中，舒张压、总胆固醇和胰岛素抵抗稳态模型评估是血浆ATGL水平的独立相关因素（Y = - 13.662 + 0.343 ×腰围+ 0.268 ×舒张压+ 0.053 × 2hPin + 0.966 ×胰岛素抵抗稳态模型评估）。这项工作提示ATGL与胰岛素抵抗和T2DM发病机制的潜在联系。
Introduction:Adipose triglyceride lipase (ATGL) is a recently identified triacylglycerol lipase responsible for adiposity lipolysis. Its pathophysiologic role in humans remains unknown. Material and Methods:In this study, the authors investigated the levels of plasma ATGL among patients with type 2 diabetes mellitus (T2DM), patients with T2DM and hypertension and control subjects. They also assessed the association between plasma ATGL and body composition and metabolic parameters. Results and Conclusions:Plasma ATGL levels significantly increased in patients with T2DM and hypertension compared with those with T2DM (78.3 ± 23.4 versus 65.1 ± 22.8 &mgr;g/L, P < 0.01). No gender differences were found among plasma ATGL levels. Furthermore, they found that the plasma ATGL level was positively correlated with total cholesterol (r = 0.17, P < 0.05) and high-density lipoprotein C (r = 0.16, P < 0.05) in simple regression analysis of pooled data, whereas, in multiple stepwise regression analysis, diastolic blood pressure, total cholesterol and homeostasis model assessment of insulin resistance were independently related factors with plasma ATGL levels (Y = −13.662 + 0.343 × waist + 0.268 × diastolic blood pressure + 0.053 × 2hPin + 0.966 × homeostasis model assessment of insulin resistance). This work indicates the potential link of ATGL with the pathogenesis of insulin resistance and T2DM.
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影响因子：
7.7
作者：
Kershaw, EE;Hamm, JK;Flier, JS
通讯作者：
Flier, JS
影响因子：
4.8
作者：
Soni, KG;Lehner, R;Mitchell, GA
通讯作者：
Mitchell, GA
DOI：
--
发表时间：
2006
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
--
作者：
Ji Young Kim;Kristin Tillison;Jun‐Ho Lee;D. Rearick;C. Smas
通讯作者：
Ji Young Kim;Kristin Tillison;Jun‐Ho Lee;D. Rearick;C. Smas
影响因子：
8.2
作者：
Festuccia, W. T.;Laplante, M.;Deshaies, Y.
通讯作者：
Deshaies, Y.
DOI：
10.1016/j.bbalip.2006.11.009
发表时间：
2007-02-01
影响因子：
4.8
作者：
Shen, Wen-Jun;Patel, Shailja;Kraemer, Fredric B.
通讯作者：
Kraemer, Fredric B.