On the Effect of Age on the Transmission of SARS-CoV-2 in Households, Schools, and the Community.
On the Effect of Age on the Transmission of SARS-CoV-2 in Households, Schools, and the Community.
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DOI：
10.1093/infdis/jiaa691
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发表时间：
2021-02-13
期刊：
影响因子：
--
通讯作者：
Cevik M
中科院分区：
文献类型：
--
作者：
Goldstein E;Lipsitch M;Cevik M
关于年龄对SARS-CoV-2感染在不同环境中传播的影响的信息有限。我们回顾了已发表的关于在COVID-19病例接触者中检测SARS-CoV-2感染的研究/数据、血清学研究和学校感染研究。与年轻/中年人相比，10岁以下儿童的感染易感性估计明显较低，而60岁以上成人的感染易感性估计较高。血清学研究表明，年轻人（特别是35岁以下的年轻人）在社区中SARS-CoV-2感染的累积发病率往往很高。有证据表明，由于控制措施有限，SARS-CoV-2可能在中学/高中强劲传播，在小学传播程度较低，班级规模可能影响传播。还有证据表明，在实施一些缓解措施后，学校中的传播更为有限。几个潜在的偏见，可能会影响这些研究进行了讨论。在开办学校，特别是中学/高中时，应采取缓解措施。应努力减少年轻人，特别是18 - 35岁的人的混合，以减缓该流行病在社区的传播。我们的文献综述表明，与年轻/中年人相比，10岁以下儿童对SARS-CoV-2感染的易感性相对较低，而60岁以上成人的易感性较高。在开办学校，特别是中学/高中时，应采取缓解措施。
There is limited information on the effect of age on the transmission of SARS-CoV-2 infection in different settings. We reviewed published studies/data on detection of SARS-CoV-2 infection in contacts of COVID-19 cases, serological studies, and studies of infections in schools. Compared to younger/middle-aged adults, susceptibility to infection for children younger than 10 years is estimated to be significantly lower, while estimated susceptibility to infection in adults older than 60 years is higher. Serological studies suggest that younger adults (particularly those younger than 35 years) often have high cumulative incidence of SARS-CoV-2 infection in the community. There is some evidence that given limited control measures, SARS-CoV-2 may spread robustly in secondary/high schools, and to a lesser degree in primary schools, with class size possibly affecting that spread. There is also evidence of more limited spread in schools when some mitigation measures are implemented. Several potential biases that may affect these studies are discussed. Mitigation measures should be implemented when opening schools, particularly secondary/high schools. Efforts should be undertaken to diminish mixing in younger adults, particularly individuals aged 18–35 years, to mitigate the spread of the epidemic in the community. Our literature review suggests that compared to younger/middle-aged adults, susceptibility to SARS-CoV-2 infection in children aged <10 years is relatively low, while susceptibility in adults aged >60 years is higher. Mitigation measures should be implemented when opening schools, particularly secondary/high schools.
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DOI：
10.2807/1560-7917.es.2020.25.36.2001587
发表时间：
2020-09
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Ehrhardt J;Ekinci A;Krehl H;Meincke M;Finci I;Klein J;Geisel B;Wagner-Wiening C;Eichner M;Brockmann SO
通讯作者：
Brockmann SO
影响因子：
33.9
作者：
Payne, Daniel C.;Smith-Jeffcoat, Sarah E.;Gillingham, Bruce L.
通讯作者：
Gillingham, Bruce L.
影响因子：
36.4
作者：
Macartney, Kristine;Quinn, Helen E.;Wood, Nicholas
通讯作者：
Wood, Nicholas
影响因子：
5.2
作者：
Kim, Jieun;Choe, Young June;Choi, Eun Hwa
通讯作者：
Choi, Eun Hwa
影响因子：
11.8
作者：
Park YJ;Choe YJ;Park O;Park SY;Kim YM;Kim J;Kweon S;Woo Y;Gwack J;Kim SS;Lee J;Hyun J;Ryu B;Jang YS;Kim H;Shin SH;Yi S;Lee S;Kim HK;Lee H;Jin Y;Park E;Choi SW;Kim M;Song J;Choi SW;Kim D;Jeon BH;Yoo H;Jeong EK;COVID-19 National Emergency Response Center, Epidemiology and Case Management Team
通讯作者：
COVID-19 National Emergency Response Center, Epidemiology and Case Management Team