Functional imaging of sleep vertex sharp transients.

Functional imaging of sleep vertex sharp transients.
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DOI:
10.1016/j.clinph.2010.12.049
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发表时间:
2011-07
期刊:
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子:
--
通讯作者:
Poldrack RA
Poldrack RA
中科院分区:
其他
文献类型:
--
作者:
Stern JM;Caporro M;Haneef Z;Yeh HJ;Buttinelli C;Lenartowicz A;Mumford JA;Parvizi J;Poldrack RA

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顶尖瞬变(VST)是一种脑电图(EEG)放电,是非REM睡眠的早期标志。自睡眠生理学研究开始以来,它就被认识到了,但它的来源和功能仍然无法解释。我们使用功能性MRI(fMRI)研究VST的产生。同时记录7名个体在困倦和浅睡眠状态下的EEG和fMRI。EEG上的VST发生与fMRI使用与血流动力学响应函数卷积的脉冲函数来建模,以识别与VST相关的大脑区域。所得的统计图像在Z>2.3下阈值化。确定了200个VST。双侧中央内侧、中央前外侧、后上级颞叶和枕内侧皮质信号明显增强。不存在信号降低的区域。这些区域与来自动物模型和人类睡眠功能成像的电生理证据一致,但结果是特定于VST的。这些区域主要包括视觉、听觉和触觉的初级感觉运动皮层区域。结果描绘了一个网络,包括假定的VST生成器及其相关区域。初级感觉的相关区域功能相似性表明VST在睡眠期间的感觉体验中的作用。
The vertex sharp transient (VST) is an electroencephalographic (EEG) discharge that is an early marker of non-REM sleep. It has been recognized since the beginning of sleep physiology research, but its source and function remain mostly unexplained. We investigated VST generation using functional MRI (fMRI). Simultaneous EEG and fMRI were recorded from 7 individuals in drowsiness and light sleep. VST occurrences on EEG were modeled with fMRI using an impulse function convolved with a hemodynamic response function to identify cerebral regions correlating to the VSTs. A resulting statistical image was thresholded at Z>2.3. Two hundred VSTs were identified. Significantly increased signal was present bilaterally in medial central, lateral precentral, posterior superior temporal, and medial occipital cortex. No regions of decreased signal were present. The regions are consistent with electrophysiologic evidence from animal models and functional imaging of human sleep, but the results are specific to VSTs. The regions principally encompass the primary sensorimotor cortical regions for vision, hearing, and touch. The results depict a network comprising the presumed VST generator and its associated regions. The associated regions functional similarity for primary sensation suggests a role for VSTs in sensory experience during sleep.
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发表时间: 2002-12-01
影响因子: 3
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发表时间: 1992-11-01
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发表时间: 1995-05-01
影响因子: 3.3
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