Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.
Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.
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DOI：
10.14814/phy2.15859
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发表时间：
2023-11
影响因子：
2.5
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中科院分区：
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对BMI匹配的正常（NGT，n = 10，41 ± 4岁，35.6 ± 3.0 kg/m2）和糖耐量异常（AGT，n = 16，51 ± 3岁，34.3 ± 1.5 kg/m2）受试者的身体成分、代谢健康（口服葡萄糖耐量试验[OGTT]）和最大摄氧量进行评价。参与者还完成了在65%VO2max下持续30分钟的跑步机步行测试。通过ELISA评估总sIgA、esIgA、sTLR 2和sTLR 4，并计算cIgA。AGT显示出更高（p < 0.05）的体脂%（+24%）、空腹血糖（+37%）、OGTT AUC（+59%）和HOMA-IR（+55%）以及更低（p < 0.05）的VO 2 max（-24%）。AGT中sTLR 2比NGT低33%（主效应，p = 0.034）。然而，sTLR 2在AE后没有变化（p > 0.05）。在AGT中sTLR 4倾向于比NGT低36%（主效应，p = 0.096），并且在AE后没有变化（p > 0.05）。两组之间的总血清和亚型相似（p > 0.05），并且在AE后没有变化（p > 0.05）。sTLR 2与基础BG（r =-0.505）和OGTT AUC（r =-0.687）相关（p < 0.05）。sTLR 4与基础BG（p < 0.10，r =-0.374）和OGTT AUC（p < 0.05，r =-0.402）相关。线性回归可预测基础状态下的sTLR（sTLR2：R2 = 0.641，p = 0.01; sTLR4：R2 = 0.566，p = 0.037）（sTLR 2：R2 = 0.681，p = 0.004，sTLR 4：R2 = 0.568，p = 0.036）。这些发现表明AGT中循环sTLR谱被破坏，并且急性AE最小程度地调节它们的水平。
BMI‐matched normal‐ (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m2) and abnormal‐glucose‐tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m2) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO2max. Participants also completed a treadmill walking test at 65% VO2max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA‐IR (+55%) and lower (p < 0.05) VO2max (−24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main effect, p = 0.096) and did not change following AE (p > 0.05). Total sRAGE and isoforms were similar (p > 0.05) between groups and did not change following AE (p > 0.05). sTLR2 was correlated with (p < 0.05) basal BG (r = −0.505) and OGTT AUC (r = −0.687). sTLR4 was correlated with basal BG (p < 0.10, r = −0.374) and OGTT AUC (p < 0.05, r = −0.402). Linear regressions were predictive of sTLRs in the basal state (sTLR2: R 2 = 0.641, p = 0.01; sTLR4: R 2 = 0.566, p = 0.037) and after acute exercise state (sTLR2: R 2 = 0.681, p = 0.004, sTLR4: R 2 = 0.568, p = 0.036).These findings show circulating sTLR profiles are disrupted in AGT and acute AE minimally modulates their levels.
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