Histogram analysis of T2 mapping for detecting early involvement of extraocular muscles in patients with thyroid-associated ophthalmopathy.
Histogram analysis of T2 mapping for detecting early involvement of extraocular muscles in patients with thyroid-associated ophthalmopathy.
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T2映射的直方图分析，用于检测甲状腺相关眼科患者的眼外肌肉早期受累。
DOI：
10.1038/s41598-020-76341-6
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发表时间：
2020-11-10
影响因子：
4.6
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Liu P;Chen L;Wang QX;Luo B;Su HH;Yuan G;Jiang GH;Zhang J
应用T2值直方图分析检测甲状腺相关性眼病（TAO）患者早期累及眼外肌（EOMs）。分析了45例TAO患者和22例健康对照（hc）各眼眶5个eom。将患者的EOMs分为受累EOMs和外观正常EOMs （NAEOMs）。比较eom的直方图参数和信号强度比（SIRs）；采用受试者工作特征（ROC）曲线分析区分naeom和HCs的eom。24例患者在免疫抑制治疗后重新评估。SIRs受累肌肉值高于NAEOMs和hc (p < 0.05)；NAEOMs与hc之间无差异（p = 0.26）。除25、50百分位和标准差（SD）外，受累肌肉参数与NAEOMs无显著差异（p < 0.05）。NAEOMs的第90、95百分位、SD、偏度、不均匀性和熵值均高于hc （p < 0.05）。ROC曲线的熵值分析得到区分NAEOMs和hc的最佳ROC曲线下面积（AUC; 0.816）。治疗后，NAEOMs的直方图参数包括第5、75、90和95个百分点、SD、峰度、不均匀性和熵均降低（p < 0.05）。T2直方图分析可在常规眼眶MRI检查前发现早期eom累及TAO。
Using histogram analysis of T2 values to detect early involvement of extraocular muscles (EOMs) in patients with thyroid-associated ophthalmopathy (TAO). Five EOMs of each orbit were analyzed for 45 TAO patients and 22 healthy controls (HCs). Patients’ EOMs were grouped into involved or normal-appearing EOMs (NAEOMs). Histogram parameters and signal intensity ratios (SIRs) of EOMs were compared; receiver operating characteristic (ROC) curve analysis was performed to differentiate NAEOMs from EOMs of HCs. 24 patients were reassessed following immunosuppressive treatment. For SIRs, involved muscles showed higher values than those of NAEOMs and HCs (p < 0.05); there were no differences between NAEOMs and HCs (p = 0.26). Parameters of involved muscles showed no different from those of NAEOMs excluding 25th, 50th percentiles, and standard deviation (SD) (p < 0.05). NAEOMs displayed higher values of 90th, 95th percentiles, SD, skewness, inhomogeneity, and entropy than HCs (p < 0.05). ROC curve analysis of entropy yielded the best area under the ROC curve (AUC; 0.816) for differentiating NAEOMs and HCs. After treatment, histogram parameters including 5th, 75th, 90th, and 95th percentiles, SD, kurtosis, inhomogeneity, and entropy were reduced in NAEOMs (p < 0.05). T2 histogram analysis could detect early involvement of EOMs in TAO prior to detection on conventional orbital MRI.
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影响因子：
2.8
作者：
Fan, Zheng;Wang, Jiahui;Ahn, Mihye;Shiloh-Malawsky, Yael;Chahin, Nizar;Elmore, Sandra;Bagnell, C. Robert, Jr.;Wilber, Kathy;An, Hongyu;Lin, Weili;Zhu, Hongtu;Styner, Martin;Kornegay, Joe N.
通讯作者：
Kornegay, Joe N.
影响因子：
2.9
作者：
Arpan, Ishu;Forbes, Sean C.;Lott, Donovan J.;Senesac, Claudia R.;Daniels, Michael J.;Triplett, William T.;Deol, Jasjit K.;Sweeney, H. Lee;Walter, Glenn A.;Vandenborne, Krista
通讯作者：
Vandenborne, Krista
影响因子：
19.7
作者：
Baessler, Bettina;Luecke, Christian;Lurz, Philipp
通讯作者：
Lurz, Philipp
影响因子：
3.9
作者：
Das, Tilak;Roos, Jonathan C. P.;Murthy, Rachna
通讯作者：
Murthy, Rachna
影响因子：
2.6
作者：
Kilicarslan, R.;Alkan, A.;Tasan, E.
通讯作者：
Tasan, E.