T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
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DOI：
10.1002/nbm.2851
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发表时间：
2013-03
影响因子：
2.9
通讯作者：
Vandenborne, Krista
中科院分区：
文献类型：
--
作者：
Arpan, Ishu;Forbes, Sean C.;Lott, Donovan J.;Senesac, Claudia R.;Daniels, Michael J.;Triplett, William T.;Deol, Jasjit K.;Sweeney, H. Lee;Walter, Glenn A.;Vandenborne, Krista
关键词：
Duchenne型肌营养不良症（DMD）患儿的骨骼肌对损伤和进行性脂质浸润的敏感性增强，这导致磁共振质子横向弛豫时间（T2）增加。因此，检查个体肌肉的T2变化可能有助于监测DMD的疾病进展。在这项研究中，我们利用平均T2，百分比升高的像素，和T2异质性，以评估营养不良的肌肉组成的变化。此外，我们使用脂肪饱和度（fatsat）来区分由于水肿和炎症引起的T2变化与肌肉中的脂肪浸润。30例DMD患者和15例年龄相匹配的对照者均行下肢T2加权成像。开发T2图，手动追踪4块小腿肌肉（比目鱼肌、内侧腓肠肌、腓骨肌和胫骨前肌）。计算跟踪的感兴趣区域（ROI）的平均T2、T2直方图的宽度和T2升高的像素。我们发现，即使在患有DMD的幼儿中，肌肉的平均T2也会升高，并且与对照组相比，小腿肌肉的像素更不均匀，并且像素升高更大。T2测量值随脂肪饱和度降低，但营养不良肌肉中的T2测量值仍高于对照组（p<0.05）。此外，T2测量与定时功能测试呈正相关（r=0.23-0.79）。与未受影响的对照组相比，在所有年龄段的DMD患者（5-15岁）中，在有和没有脂肪饱和的情况下，T2测量值升高，表明营养不良的肌肉具有增加的损伤、水肿和脂肪浸润区域。这项研究表明，T2映射提供了多种方法，可以有效地用于表征DMD儿童的肌肉组织，即使在疾病的早期阶段。因此，T2标测可能在临床上用于监测DMD中由于疾病过程或治疗干预引起的肌肉变化。
Skeletal muscles of children with Duchenne muscular dystrophy (DMD) have enhanced susceptibility to damage and progressive lipid infiltration, which contribute to an increase in magnetic resonance proton transverse relaxation time (T2). Therefore, examining T2 changes in individual muscles may be useful for monitoring disease progression in DMD. In this study we utilized mean T2, percent elevated pixels, and T2 heterogeneity to assess changes in composition of dystrophic muscles. In addition, we used fat saturation (fatsat) to distinguish T2 changes due to edema and inflammation from fat infiltration in muscles. Thirty subjects with DMD and 15 age-matched controls underwent T2-weighted imaging of their lower leg using 3-T MR system. T2 maps were developed and four lower leg muscles were manually traced (soleus, medial gastrocnemius, peroneal and tibialis anterior). Mean T2 of the traced regions of interest (ROI), width of T2 histograms, and percent-elevated pixels were calculated. We found that even in young children with DMD, muscles had elevated mean T2, were more heterogeneous, and had a greater percent-elevated pixels in the lower leg muscles than controls. T2 measures decreased with fat saturation, but were still higher (p<0.05) in dystrophic muscles than controls. Further, T2 measures showed positive correlations with timed functional tests (r=0.23–0.79). The elevated T2 measures with and without fat saturation in all ages of DMD examined (5–15 years) compared to unaffected controls indicate that the dystrophic muscles have increased regions of damage, edema, and fat infiltration. This study shows that T2 mapping provides multiple approaches that can be effectively utilized to characterize muscle tissue in children with DMD even in the early stages of the disease. Therefore, T2 mapping may prove clinically useful in monitoring muscle changes due to disease process or therapeutic interventions in DMD.
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影响因子：
2.4
作者：
Gaudreault, Nathaly;Gravel, Denis;Gagnon, Denis
通讯作者：
Gagnon, Denis
影响因子：
5.5
作者：
Maillard, SM;Jones, R;Murray, KJ
通讯作者：
Murray, KJ
影响因子：
158.5
作者：
Goemans, Nathalie M.;Tulinius, Mar;van Deutekom, Judith C.
通讯作者：
van Deutekom, Judith C.
DOI：
10.1002/jmri.1880040113
发表时间：
1994-01-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
HUANG, YM;MAJUMDAR, S;MILLER, RG
通讯作者：
MILLER, RG
影响因子：
3.3
作者：
Gambarota, G;Cairns, BE;Mulkern, RV
通讯作者：
Mulkern, RV