Selective Photocleavage of DNA and RNA by Anthraquinone Derivatives: Targeting the Single‐Strand Region of Hairpin Structures
Selective Photocleavage of DNA and RNA by Anthraquinone Derivatives: Targeting the Single‐Strand Region of Hairpin Structures
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蒽醌衍生物对 DNA 和 RNA 的选择性光裂解：靶向发夹结构的单链区域
DOI：
10.1111/j.1751-1097.1999.tb08292.x
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发表时间：
1999
影响因子：
3.3
通讯作者：
G. Schuster
中科院分区：
文献类型：
--
作者：
Maria Fernandez;P. Henderson;W. Wilson;G. Schuster
一个四聚蒽醌衍生物（27AQS2）与发夹DNA和RNA结合。结合醌的紫外线照射导致DNA发夹茎区的寡核苷酸环区和鸟嘌呤环区发生裂解。在RNA发夹中没有观察到的鸟嘌呤链切割，这表明苯胺处理不会引起RNA中受损鸟嘌呤的切割，或者自由基阳离子迁移不容易发生在RNA双链中。靶向DNA和RNA结构单链区域的能力是该光核酸酶的重要特性。
A tetracationic anthraquinone derivative (27AQS2) binds to hairpin DNA and RNA. Ultraviolet irradiation of the bound quinone causes cleavage in the loop region of both oligonucleotides and at guanines in the stem region of the DNA hairpin. The absence of observable strand cleavage at guanines in the RNA hairpin suggests that either aniline treatment does not cause cleavage at damaged guanines in RNA or that radical cation migration does not occur readily in RNA duplexes. The ability to target the single‐stranded regions of DNA and RNA structures is an important property of this photonuclease.
蒽醌衍生物对 DNA 的选择性光裂解：靶向发夹结构的单链区域。
DOI：
10.1021/bi972419g
发表时间：
1998
期刊：
Biochemistry.
影响因子：
--
作者：
Henderson,PT;Armitage,B;Schuster,GB
通讯作者：
Schuster,GB
影响因子：
--
作者：
Arkin, MR;Stemp, EDA;Barton, JK
通讯作者：
Barton, JK