Decrease of infectious complications in outpatients with autoimmune diseases from 2019 to 2020 under the COVID-19 pandemic: A single-centre, retrospective cohort study in Japan.
Decrease of infectious complications in outpatients with autoimmune diseases from 2019 to 2020 under the COVID-19 pandemic: A single-centre, retrospective cohort study in Japan.
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DOI：
10.1093/mr/roab080
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发表时间：
2022-02-28
影响因子：
2.2
通讯作者：
Kameoka J
中科院分区：
文献类型：
--
作者：
Oka Y;Kodera T;Takeshita M;Shirota Y;Takeda T;Tsutsumi T;Kameoka J
研究新型冠状病毒病（COVID-19）如何改变自身免疫性疾病门诊患者的感染性并发症。我们对2019年和2020年来我科就诊的患者进行了一项回顾性、记录关联队列研究和关于生活方式变化的问卷调查。我们在2019年调查了1316名门诊患者，2020年调查了1284名。最常见的基础疾病是类风湿性关节炎（842 vs. 814）和系统性红斑狼疮（126 vs. 127）。两年内的中位年龄（66岁vs. 67岁）、呼吸系统合并症（30.4% vs. 32.0%）或皮质类固醇使用率（42.2% vs. 44.3%）无显著差异。2020年，免疫调节剂的使用率更高（33.1% vs. 39.7%，p<.001）。2020年的感染总数（28.0/100对比19.4/100人年）、肺炎（3.6对比1.6）、流感（2.1对比0.1）和非病毒性皮肤病感染（3.8对比2.1）显著下降。带状疱疹（2.2 vs. 1.8）、尿路感染（3.3 vs. 3.8）或胃肠道感染（2.9 vs. 3.0）无显著差异。问卷显示，疫情期间，75%的受访者佩戴口罩意识增强，81%的人开始使用洗手液。在COVID-19大流行下，自身免疫性疾病门诊患者的一些感染性并发症有所减少。
To examine how the novel coronavirus disease (COVID-19) has changed infectious complications in outpatients with autoimmune diseases. We performed a retrospective, record-linked cohort study and questionnaire about lifestyle changes in patients who visited our department in 2019 and 2020. We surveyed 1316 outpatients in 2019 and 1284 in 2020. The most common underlying diseases were rheumatoid arthritis (842 vs. 814) and systemic lupus erythematosus (126 vs. 127). No significant difference in median age (66 vs. 67 years), respiratory comorbidities (30.4% vs. 32.0%), or corticosteroid use (42.2% vs. 44.3%) was found between the years. Immunomodulating agents were used more in 2020 (33.1% vs. 39.7%, p<.001). Total number of infections (28.0/100 vs. 19.4/100 person-years), pneumonia (3.6 vs. 1.6), influenza (2.1 vs. 0.1), and non-viral dermatological infections (3.8 vs. 2.1) were significantly lower in 2020. No significant difference was found for herpes zoster (2.2 vs. 1.8), urinary tract infections (3.3 vs. 3.8), or gastrointestinal infections (2.9 vs. 3.0). According to the questionnaire, 75% of the respondents became more conscious about wearing masks and 81% began to use hand sanitizer during the pandemic. Under the COVID-19 pandemic, some infectious complications have decreased in outpatients with autoimmune diseases.
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