Coordination of progenitor specification and growth in mouse and chick spinal cord.
Coordination of progenitor specification and growth in mouse and chick spinal cord.
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DOI：
10.1126/science.1254927
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发表时间：
2014-09-26
期刊：
影响因子：
--
通讯作者：
Briscoe J
中科院分区：
文献类型：
--
作者：
Kicheva A;Bollenbach T;Ribeiro A;Valle HP;Lovell-Badge R;Episkopou V;Briscoe J
发育需要组织生长以及细胞多样化。为了解决这些过程是如何协调的，我们分析了小鼠和鸡神经管中神经祖细胞分子上不同结构域的发育。我们表明，在发展过程中，这些领域经历的变化，不规模与整体组织大小的变化。我们的数据表明，域的比例首先建立了相反的形态梯度，随后控制域特异性调节分化率，但不是增殖率的差异。分化率的调节是维持结构域比例的关键，同时适应物种内和物种间的大小变化。因此，祖细胞特化和分化的顺序控制阐述了模式，而不需要信号梯度随着组织扩张而增长。
Development requires tissue growth as well as cell diversification. To address how these processes are coordinated, we analyzed the development of molecularly distinct domains of neural progenitors in the mouse and chick neural tube. We show that during development these domains undergo changes in size that do not scale with changes in overall tissue size. Our data show that domain proportions are first established by opposing morphogen gradients and subsequently controlled by domain specific regulation of differentiation rate, but not differences in proliferation rate. Regulation of differentiation rate is key to maintaining domain proportions while accommodating both intra- and interspecies variations in size. Thus the sequential control of progenitor specification and differentiation elaborates pattern without requiring that signalling gradients grow as tissues expand.
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影响因子：
9.8
作者：
Dessaud E;Ribes V;Balaskas N;Yang LL;Pierani A;Kicheva A;Novitch BG;Briscoe J;Sasai N
通讯作者：
Sasai N
影响因子：
9.8
作者：
Boehm B;Westerberg H;Lesnicar-Pucko G;Raja S;Rautschka M;Cotterell J;Swoger J;Sharpe J
通讯作者：
Sharpe J
影响因子：
64.5
作者：
Inomata, Hidehiko;Shibata, Tatsuo;Sasai, Yoshiki
通讯作者：
Sasai, Yoshiki
DOI：
10.1073/pnas.0509483102
发表时间：
2005-12-20
影响因子：
11.1
作者：
Gregor, T;Bialek, W;Wieschaus, EF
通讯作者：
Wieschaus, EF
影响因子：
9.8
作者：
Hamaratoglu, Fisun;de Lachapelle, Aitana Morton;Affolter, Markus
通讯作者：
Affolter, Markus