Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults.
Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults.
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DOI：
10.1002/trc2.12129
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
on behalf of the PACt‐MD Study Group
中科院分区：
文献类型：
--
作者：
Diniz BS;Vieira EM;Mendes-Silva AP;Bowie CR;Butters MA;Fischer CE;Flint A;Herrmann N;Kennedy J;Lanctôt KL;Mah L;Pollock BG;Mulsant BH;Rajji TK;on behalf of the PACt‐MD Study Group
轻度认知障碍(MCI)和重度抑郁障碍的生物学机制还不是很清楚。我们调查了老年人的分子衰老变化是否与严重抑郁障碍(MDD)或MCI的病史有关。我们纳入了371名参与者：167名MCI患者；62名有MDD病史的认知正常者；97名MDD+MCI患者；45名没有MDD病史的认知正常(CU)患者。使用定制的Luminex试验在血浆中测量候选衰老相关分泌表型(SASP)生物标志物。MDD+MCI组SASP指数高于其他组(P<0.01)。SASP指数较高与较差的整体认知表现、执行功能障碍、较慢的处理速度和情景记忆缺陷显著相关。我们的研究表明，在患有MDD的老年人中，分子变化的增加与认知障碍有关，并表明加速的生物衰老是MDD的一个潜在特征。
The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI. We included 371 participants: 167 with MCI; 62 cognitively normal with a history of MDD; 97 with MDD+MCI; and 45 cognitively unimpaired (CU) without a history of MDD. The candidate Senescence‐Associated Secretory Phenotype (SASP) biomarkers were measured in the plasma using a customized LUMINEX assay. The MDD+MCI group had a higher SASP index than the other groups (P < .001). A higher SASP index was significantly associated with worse global cognitive performance, executive dysfunction, slower processing speed, and episodic memory deficits. Our study suggests that increased molecular changes are associated with cognitive impairment in older adults with MDD and indicate that accelerated biological aging is an underlying feature of MDD.
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影响因子：
3.7
作者：
Coppé JP;Patil CK;Rodier F;Krtolica A;Beauséjour CM;Parrinello S;Hodgson JG;Chin K;Desprez PY;Campisi J
通讯作者：
Campisi J
DOI：
10.3233/jad-2012-112009
发表时间：
2012
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Geerlings MI;Brickman AM;Schupf N;Devanand DP;Luchsinger JA;Mayeux R;Small SA
通讯作者：
Small SA
影响因子：
4.8
作者：
Diniz, Breno Satler;Lin, Chien-Wei;Butters, Meryl A.
通讯作者：
Butters, Meryl A.
影响因子：
3.9
作者：
Chinta, Shankar J.;Woods, Georgia;Andersen, Julie K.
通讯作者：
Andersen, Julie K.
影响因子：
9.3
作者：
Bachstetter, Adam D.;Xing, Bin;Van Eldik, Linda J.
通讯作者：
Van Eldik, Linda J.